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Title: Human hydroxytyrosol's absorption and excretion from a nutraceutical
Author: Khymenets, Olha
Crespo, M. Carmen
Dangles, Olivier
Rakotomanomana, N.
Andrés Lacueva, Ma. Cristina
Visioli, F. (Francesco)
Keywords: Salut
Suplements nutritius
Espectrometria de masses
Assaigs clínics
Dietary supplements
Mass spectrometry
Clinical trials
Issue Date: 31-Mar-2016
Publisher: Elsevier
Abstract: Among the various (poly)phenols that are being sold as such or as part of a more complex mixture, hydroxytyrosol (HT) is the only one that bears a European Food Safety Authority health claim. Therefore, several HT-based products are being developed and sold and it becomes necessary to evaluate its accessibility following ingestion. Twenty-one volunteers were recruited for a randomized, crossover, placebo-controlled, and double-blind intervention study.We performed a Latin square design: after one-week washout, i.e. olive-free diet, subjects were randomly assigned to the placebo (maltodextrin), 5, or 25 mg/day HT group. Twenty-four hour urine samples were collected after the intervention week, and baseline urines were collected the week before the study and during periods of washout. The results show that HT given as the foremost component of a nutraceutical preparation is bioavailable and is recovered in the urine chiefly as sulphate-3′.
Note: Versió postprint del document publicat a:
It is part of: Journal of Functional Foods, 2016, vol. 23, num. , p. 278-282
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ISSN: 1756-4646
Appears in Collections:Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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