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Title: Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes
Author: Tulipani, Sara
Palau Rodríguez, Magalí
Miñarro Alonso, Antonio
Cardona, Fernando
Marco Ramell, Anna
Zonja, Bozo
López de Alda, Miren
Muñoz-Garach, Araceli
Sànchez, Àlex (Sànchez Pla)
Tinahones, Francisco J.
Andrés Lacueva, Ma. Cristina
Keywords: Obesitat
Marcadors bioquímics
Diabetis no-insulinodependent
Resistència a la insulina
Espectrometria de masses
Biochemical markers
Non-insulin-dependent diabetes
Insulin resistance
Mass spectrometry
Issue Date: 5-Oct-2016
Publisher: Elsevier B.V.
Abstract: Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS-driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=-0.56, p=0.0003; lysoPC C18:1: R=-0.61, p=0.0001; lysoPC C18:2 R=-0.64, p<0.0001]. Several amino acids were biomarkers of risk of diabetes onset associated to obesity. For instance, glutamate significantly associated with fasting insulin [R=0.5, p=0.0019] and HOMA-IR [R=0.46, p=0.0072], while glycine showed negative associations [fasting insulin: R=-0.51, p=0.0017; HOMA-IR: R=-0.49, p=0.0033], and the branched chain amino acid valine associated to prediabetes and insulin resistance in a BMI-independent manner [fasting insulin: R=0.37, p=0.0479; HOMA-IR: R=0.37, p=0.0468]. Minority sphingolipids including specific [dihydro]ceramides and sphingomyelins also associated with the prediabetic insulin resistant state, hence deserving attention as potential targets for early diagnosis or therapeutic intervention.
Note: Versió postprint del document publicat a:
It is part of: Clinica Chimica Acta, 2016, vol. 463, p. 53-61
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ISSN: 0009-8981
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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