Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/164264
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dc.contributor.authorFernández-Bañares, Fernando-
dc.contributor.authorClèries Soler, Ramon-
dc.contributor.authorBoadas, Jaume-
dc.contributor.authorRibes Puig, Josepa-
dc.contributor.authorOliva, Joan Carles-
dc.contributor.authorAlsius, Antoni-
dc.contributor.authorSanz, Xavier-
dc.contributor.authorMartínez-Bauer, Eva-
dc.contributor.authorGalter, Sara-
dc.contributor.authorPujals, Mar-
dc.contributor.authorPujol, Marta-
dc.contributor.authorDel Pozo, Patricia-
dc.contributor.authorCampo Fernández de los Rios, Rafael-
dc.date.accessioned2020-06-04T10:21:30Z-
dc.date.available2020-06-04T10:21:30Z-
dc.date.issued2019-07-25-
dc.identifier.issn1471-2407-
dc.identifier.urihttp://hdl.handle.net/2445/164264-
dc.description.abstractBackground: Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neoplasia in symptomatic patients in fast-track programs. Methods: All patients referred for fast-track colonoscopy were evaluated. Faecal immunological haemoglobin test (3 samples; positive> 4 μg Hb/g), and a survey to register clinical variables of interest were performed. Colorectal cancer and advanced adenoma were considered as advanced colonic neoplasia. A sample size of 600 and 500 individuals were calculated for each phase 1 and phase 2 of the study, respectively (Phase 1, derivation and Phase 2, validation cohort). A Bayesian logistic regression analysis was used to derive a predictive score. Results: 1495 patients were included. Age (OR, 21), maximum faecal-Hb value (OR, 2.3), and number of positive samples (OR, 28) presented the highest ORs predictive of advanced colonic neoplasia. The additional significant predictive variables adjusted for age and faecal-Hb variables in Phase 1 were previous colonoscopy (last 5 years) and smoking (no, ex/active). With these variables a predictive score of advanced colonic neoplasia was derived. Applied to Phase 2, patients with a Score > 20 had an advanced colonic neoplasia probability of 66% (colorectal cancer, 32%), while those with a Score ≤ 10, a probability of 10% (colorectal cancer, 1%). Prioritizing patients with Score > 10, 49.4% of patients would be referred for fast-track colonoscopy, diagnosing 98.3% of colorectal cancers and 77% of advanced adenomas. Conclusions: A scoring system was derived and validated to prioritize fast-track colonoscopies according to risk, which was efficient, simple, and robust.-
dc.format.extent12 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherBioMed Central-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1186/s12885-019-5926-4-
dc.relation.ispartofBMC Cancer, 2019, vol. 19, p. 734-
dc.relation.urihttps://doi.org/10.1186/s12885-019-5926-4-
dc.rightscc-by (c) Fernández-Bañares, Fernando et al., 2019-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.subject.classificationColonoscòpia-
dc.subject.classificationCàncer colorectal-
dc.subject.classificationTumors-
dc.subject.classificationHemoglobina-
dc.subject.otherColonoscopy-
dc.subject.otherColorectal cancer-
dc.subject.otherTumors-
dc.subject.otherHemoglobin-
dc.titlePrediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study).-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec695854-
dc.date.updated2020-06-04T10:21:31Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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