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Title: A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-episilicine
Author: Amat Tusón, Mercedes
Llor Brunés, Núria
Checa Castaño, Begoña
Molins i Grau, Elies
Bosch Cartes, Joan
Keywords: Alcaloides
Síntesi asimètrica
Asymmetric synthesis
Issue Date: 1-Jan-2010
Publisher: American Chemical Society
Abstract: Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group.
Note: Versió postprint del document publicat a:
It is part of: Journal of Organic Chemistry, 2010, vol. 75, num. 1, p. 178-189
Related resource:
ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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