Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/164424
Title: Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy
Author: Moles-Aranda, Cristina
Calpena Campmany, Ana Cristina
Halbaut, Lyda
Díaz-Tomé, Victoria
Otero Espinar, Francisco J.
Morales-Molina, José A.
Clares, Beatriz
Keywords: Solucions polimèriques
Àcid hialurònic
Pòlips (Patologia)
Tumors
Endoscòpia
Polymer solutions
Hyaluronic acid
Polyps (Pathology)
Tumors
Endoscopy
Issue Date: 2-Apr-2020
Publisher: MDPI
Abstract: Abstract: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are two techniques used in resection of gastrointestinal mucosal polyps. The aim of this work was the development and evaluation of an innovative polymeric solution containing sodium carboxymethylcellulose and hyaluronic acid. For this purpose several mixtures of these two main components, as well as others components such as fructose, citric acid and zinc, was evaluated in terms of physicochemical and microbiological properties, rheological behavior, extensibility, syringeability and stability at different storage conditions. Furthermore, the potential production of mucosal elevation and duration was also studied by an ex vivo model using porcine stomach and colon. Results showed that developed polymeric solutions possessed optimal values of pH from 4.58 to 6.63 for its use in the gastrointestinal tract. Formulations exhibited both Newtonian and pseudoplastic behaviors with different viscosity values as a function of their composition. All formulations exhibited high stability properties and no bacterial or fungal growth was detected. MCS01 and MCS05 were the polymeric solutions with best syringeability results. In this line, MCS05 was the formulation that provided the highest, 2.20 ± 0.18 cm and 1.40 ± 0.11 cm, and longest-lasting, for more than 120 min, elevation effect on porcine submucosal stomach and colon tissues, respectively. Thus, it can be concluded that polymeric solution MCS05 might be considered as a promising tool for use in human EMR and ESD.
Note: Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics12040322
It is part of: Pharmaceutics, 2020, vol. 12, num. 4, p. 322
URI: http://hdl.handle.net/2445/164424
Related resource: https://doi.org/10.3390/pharmaceutics12040322
ISSN: 1999-4923
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Files in This Item:
File Description SizeFormat 
700515.pdf2.83 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons