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http://hdl.handle.net/2445/164462
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DC Field | Value | Language |
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dc.contributor.author | Cabré, Albert | - |
dc.contributor.author | Romagnoli, Elia | - |
dc.contributor.author | Martínez-Balart, Pol | - |
dc.contributor.author | Verdaguer i Espaulella, Xavier | - |
dc.contributor.author | Riera i Escalé, Antoni | - |
dc.date.accessioned | 2020-06-05T11:13:25Z | - |
dc.date.available | 2020-11-08T06:10:25Z | - |
dc.date.issued | 2019-11-08 | - |
dc.identifier.issn | 1523-7060 | - |
dc.identifier.uri | http://hdl.handle.net/2445/164462 | - |
dc.description.abstract | The iridium-catalyzed asymmetric hydrogenation of 2-aryl allyl phthalimides to afford enantioenriched β-aryl-β-methyl amines is presented. Recently developed Ir-MaxPHOX catalysts are used for this enantioselective transformation. The mild reaction conditions and the feasible removal of the phthalimido group makes this catalytic method easily scalable and of great interest to afford chiral amines. The importance of this new methodology is exemplified by the formal synthesis of (R)-Lorcaserin, OTS514 and enantiomerically enriched 3-methyl indolines. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acs.orglett.9b03865 | - |
dc.relation.ispartof | Organic Letters, 2019, vol. 21, num. 23, p. 9709-9713 | - |
dc.relation.uri | https://doi.org/10.1021/acs.orglett.9b03865 | - |
dc.rights | (c) American Chemical Society , 2019 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Hidrogenació | - |
dc.subject.classification | Catàlisi asimètrica | - |
dc.subject.classification | Amines | - |
dc.subject.other | Hydrogenation | - |
dc.subject.other | Enantioselective catalysis | - |
dc.subject.other | Amines | - |
dc.title | Highly enantioselective iridium-catalyzed hydrogenation of 2-aryl allyl phthalimides | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 695287 | - |
dc.date.updated | 2020-06-05T11:13:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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695287.pdf | 804.1 kB | Adobe PDF | View/Open |
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