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dc.contributor.authorRomero, M.-
dc.contributor.authorZanuy, M.-
dc.contributor.authorRosell, E.-
dc.contributor.authorCascante i Serratosa, Marta-
dc.contributor.authorPiulats, J.-
dc.contributor.authorFont Bardia, Ma. Mercedes-
dc.contributor.authorBalzirini, J.-
dc.contributor.authorde Clercq, E.-
dc.contributor.authorPujol Dilmé, M. Dolors-
dc.description.abstractThe aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinium to xanthatin via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.-
dc.format.extent26 p.-
dc.publisherElsevier Masson SAS-
dc.relation.isformatofVersió postprint del document publicat a:
dc.relation.ispartofEuropean Journal of Medicinal Chemistry, 2015, vol. 90, p. 491-496-
dc.rights(c) Elsevier Masson SAS, 2015-
dc.subject.classificationPlantes medicinals-
dc.subject.classificationMedicaments antivírics-
dc.subject.otherMedicinal plants-
dc.subject.otherAntiviral agents-
dc.subject.otherX-ray crystallography-
dc.titleOptimization of Xanthatin Extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties-
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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