Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/164817
Title: Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood
Author: Prats Soteras, Xavier
Jurado, Ma. Ángeles (María Ángeles)
Ottino González, Jonatan
García García, Isabel (Biòloga)
Segura i Fàbregas, Bàrbara
Caldú i Ferrús, Xavier
Sánchez-Garre, Consuelo
Miró, N.
Tor, C.
Sender Palacios, María José
Garolera i Freixa, Maite
Keywords: Inflamació
Escorça cerebral
Pes corporal
Adolescents
Inflammation
Cerebral cortex
Body weight
Teenagers
Issue Date: 20-May-2020
Publisher: Nature Publishing Group
Abstract: Background/objectives Excessive body mass index (BMI) has been linked to a low-grade chronic inflammation state. Unhealthy BMI has also been related to neuroanatomical changes in adults. Research in adolescents is relatively limited and has produced conflicting results. This study aims to address the relationship between BMI and adolescents'brain structure as well as to test the role that inflammatory adipose-related agents might have over this putative link. Methods We studied structural MRI and serum levels of interleukin-6, tumor necrosis factor alpha (TNF-α), C-reactive protein and fibrinogen in 65 adolescents (aged 12-21 years). Relationships between BMI, cortical thickness and surface area were tested with a vertex-wise analysis. Subsequently, we used backward multiple linear regression models to explore the influence of inflammatory parameters in each brain-altered area. Results We found a negative association between cortical thickness and BMI in the left lateral occipital cortex (LOC) and the right precentral gyrus as well as a positive relationship between surface area and BMI in the left rostral middle frontal gyrus and the right superior frontal gyrus. In addition, we found that higher fibrinogen serum concentrations were related to thinning within the left LOC (β=−0.45,p< 0.001), while higher serum levels of TNF-αwere associated to a greater surface area in the right superior frontal gyrus (β=0.32,p=0.045). Besides, we have also identified a trend that negatively correlates the cortical thickness of the left fusiform gyrus with the increases in BMI. It was also associated to fibrinogen(β=−0.33,p=0.035). Conclusions These results suggest that adolescents'body mass increases are related with brain abnormalities in areas that could play a relevant role in some aspects of feeding behavior. Likewise, we have evidenced that these cortical changes were partially explained by inflammatory agents such as fibrinogen and TNF-α.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/s41366-020-0582-y
It is part of: International Journal of Obesity, 2020
URI: http://hdl.handle.net/2445/164817
Related resource: https://doi.org/10.1038/s41366-020-0582-y
ISSN: 0307-0565
Appears in Collections:Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
Articles publicats en revistes (Institut de Neurociències (UBNeuro))

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