Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/164841
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dc.contributor.authorGuillén, E.-
dc.contributor.authorGonzález Gazulla, Asensio-
dc.contributor.authorLópez Martínez, Ma. Concepción-
dc.contributor.authorBasu, P.K.-
dc.contributor.authorGhosh, A.-
dc.contributor.authorFont Bardia, Ma. Mercedes-
dc.contributor.authorCalvis, C.-
dc.contributor.authorMesseguer i Peypoch, Ramon-
dc.date.accessioned2020-06-08T18:10:14Z-
dc.date.available2020-06-08T18:10:14Z-
dc.date.issued2015-07-07-
dc.identifier.issn1434-1948-
dc.identifier.urihttp://hdl.handle.net/2445/164841-
dc.description.abstractThe study of the reactivity of the pyrazole derivative 1-[MeO-(CH2)2]-3,5-Ph2-4-(CH2Fc) (C3N2) (1, Fc = ferrocenyl) with Na2[PdCl4], Pd(OAc)2, and [MCl2(dmso)2] (M = Pd or Pt,dmso = dimethyl sulfoxide) has allowed us to isolate trans-[Pd{κ-N-(1-{MeO(CH2)2}-3,5-Ph2-4-{CH2Fc} {C3N2})}2Cl2] (2), [Pd{κ2-C,N(1-{MeO(CH2)2}-3-{C6H4}-5-Ph-{C3N2})}{κ-N-(1-{MeO(CH2)2}-3,5-Ph2-4-{CH2Fc} {C3N2})}Cl] (3), [Pd{κ2-C,N(1-{MeO(CH2)2}-3-{C6H4}-4-{CH2Fc}-5-Ph-{C3N2})}Cl-(PPh3)] (4), and the trans (5) and cis (6) isomers of [Pt{κ-N-(1-{MeO(CH2)2}-3,5-Ph24-{CH2Fc} {C3N2})}Cl2(dmso)]. Compound 1 acts as a N (in 2, 5, and 6) or (C,N) donor ligand (in 4) and shows both binding modes in 3. The cytotoxic assessment of 1 6 against MCF7, MDA-MB231 (breast), and HCT-116 (colon) cancer cell lines reveal that (1) 1 is more potent than 1-[MeO(CH2)2]-3,5-Ph2-(C3HN2) (V), (2) 2 6 have cytotoxic activity, (3) 2 and 3 are less active than 4 6, and (4) 6 is the most potent compound against the three cancer cell lines.-
dc.format.extent29 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/ejic.201500520-
dc.relation.ispartofEuropean Journal of Inorganic Chemistry, 2015, vol. 2015, num. 22, p. 3781-3791-
dc.relation.urihttps://doi.org/10.1002/ejic.201500520-
dc.rights(c) Wiley-VCH, 2015-
dc.subject.classificationCompostos metàl·lics-
dc.subject.classificationPal·ladi (Element químic)-
dc.subject.classificationPlatí-
dc.subject.classificationTumors-
dc.subject.otherMetallic composites-
dc.subject.otherPalladium-
dc.subject.otherPlatinum-
dc.subject.otherTumors-
dc.titleHeterodi- (Fe, Pd/Pt) and heterotrimetallic (Fe2, Pd) complexes derived from 4-(ferrocenylmethyl)-N-(2-methoxyethyl)-3,5-diphenylpyrazole as potential antitumoral agents-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec653888-
dc.date.updated2020-06-08T18:10:15Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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