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http://hdl.handle.net/2445/164841
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DC Field | Value | Language |
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dc.contributor.author | Guillén, E. | - |
dc.contributor.author | González Gazulla, Asensio | - |
dc.contributor.author | López Martínez, Ma. Concepción | - |
dc.contributor.author | Basu, Pradipta K. | - |
dc.contributor.author | Ghosh, A. | - |
dc.contributor.author | Font Bardia, Ma. Mercedes | - |
dc.contributor.author | Calvis, C. | - |
dc.contributor.author | Messeguer i Peypoch, Ramon | - |
dc.date.accessioned | 2020-06-08T18:10:14Z | - |
dc.date.available | 2020-06-08T18:10:14Z | - |
dc.date.issued | 2015-07-07 | - |
dc.identifier.issn | 1434-1948 | - |
dc.identifier.uri | http://hdl.handle.net/2445/164841 | - |
dc.description.abstract | The study of the reactivity of the pyrazole derivative 1-[MeO-(CH2)2]-3,5-Ph2-4-(CH2Fc) (C3N2) (1, Fc = ferrocenyl) with Na2[PdCl4], Pd(OAc)2, and [MCl2(dmso)2] (M = Pd or Pt,dmso = dimethyl sulfoxide) has allowed us to isolate trans-[Pd{κ-N-(1-{MeO(CH2)2}-3,5-Ph2-4-{CH2Fc} {C3N2})}2Cl2] (2), [Pd{κ2-C,N(1-{MeO(CH2)2}-3-{C6H4}-5-Ph-{C3N2})}{κ-N-(1-{MeO(CH2)2}-3,5-Ph2-4-{CH2Fc} {C3N2})}Cl] (3), [Pd{κ2-C,N(1-{MeO(CH2)2}-3-{C6H4}-4-{CH2Fc}-5-Ph-{C3N2})}Cl-(PPh3)] (4), and the trans (5) and cis (6) isomers of [Pt{κ-N-(1-{MeO(CH2)2}-3,5-Ph24-{CH2Fc} {C3N2})}Cl2(dmso)]. Compound 1 acts as a N (in 2, 5, and 6) or (C,N) donor ligand (in 4) and shows both binding modes in 3. The cytotoxic assessment of 1 6 against MCF7, MDA-MB231 (breast), and HCT-116 (colon) cancer cell lines reveal that (1) 1 is more potent than 1-[MeO(CH2)2]-3,5-Ph2-(C3HN2) (V), (2) 2 6 have cytotoxic activity, (3) 2 and 3 are less active than 4 6, and (4) 6 is the most potent compound against the three cancer cell lines. | - |
dc.format.extent | 29 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/ejic.201500520 | - |
dc.relation.ispartof | European Journal of Inorganic Chemistry, 2015, vol. 2015, num. 22, p. 3781-3791 | - |
dc.relation.uri | https://doi.org/10.1002/ejic.201500520 | - |
dc.rights | (c) Wiley-VCH, 2015 | - |
dc.source | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) | - |
dc.subject.classification | Compostos metàl·lics | - |
dc.subject.classification | Pal·ladi (Element químic) | - |
dc.subject.classification | Platí | - |
dc.subject.classification | Tumors | - |
dc.subject.other | Metallic composites | - |
dc.subject.other | Palladium | - |
dc.subject.other | Platinum | - |
dc.subject.other | Tumors | - |
dc.title | Heterodi- (Fe, Pd/Pt) and heterotrimetallic (Fe2, Pd) complexes derived from 4-(ferrocenylmethyl)-N-(2-methoxyethyl)-3,5-diphenylpyrazole as potential antitumoral agents | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 653888 | - |
dc.date.updated | 2020-06-08T18:10:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
Files in This Item:
File | Description | Size | Format | |
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653888.pdf | 2.19 MB | Adobe PDF | View/Open |
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