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Title: Identification Of Actionable Genetic Targets In Primary Cardiac Sarcomas
Author: Salvador Coloma, Carmen
Saigí, Maria
Díaz Beveridge, Roberto
Penín, Rosa
Pané Foix, María
Mayordomo, Empar
Melián, Marcos
Schuler, Mona
García del Muro Solans, Xavier
Font de Mora, Jaime
Keywords: Sarcoma
Malalties del cor
Heart diseases
Issue Date: 7-Nov-2019
Publisher: Dove Medical Press
Abstract: Background: Primary cardiac tumors are extremely rare; most are myxomas with a benign prognosis. However, primary sarcomas are highly aggressive and treatment options are limited. Radical surgery is often not feasible and conventional therapies provide only modest results. Due to the rare nature of primary cardiac tumors, there are no proper randomized studies to guide treatment. Their complexity requires alternative approaches in order to improve treatment efficacy. Methods: We isolated DNA from 5 primary cardiac sarcomas; the quality of DNA from 3 of them was sufficient to perform high-resolution single nucleotide polymorphism (SNP) array analysis. Results: In the present study, molecular karyotyping revealed numerous segmental chromosomal alterations and amplifications affecting actionable genes that may be involved in disease initiation and/or progression. These include chromosomal break flanking AKT2 in undifferentiated pleomorphic rhabdomyosarcoma, chromosomal break in promoter of TERT, and gain of CDK4 and amplification of MDM2 in inflammatory myofibroblastic tumor. We detected segmental break flanking MOS in high-grade myxofibrosarcoma. In addition, the high number of chromosomal aberrations in high-grade myxofibrosarcoma may cause multiple tumor-specific epitopes, supporting the study of immunotherapy treatment in this type of aggressive tumor. Conclusion: Our results provide a genetic rationale that supports an alternative, personalized therapeutic management of primary cardiac sarcomas.
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It is part of: OncoTargets and Therapy, 2019, vol. 2019, num. 12, p. 9265-9275
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ISSN: 1178-6930
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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