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http://hdl.handle.net/2445/164959
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DC Field | Value | Language |
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dc.contributor.author | Bortolozzi Biasoni, Analía | - |
dc.contributor.author | Masana Nadal, Mercè | - |
dc.contributor.author | Díaz Mataix, Llorenç | - |
dc.contributor.author | Cortés, Roser | - |
dc.contributor.author | Scorza, María Cecilia | - |
dc.contributor.author | Gingrich, Jay A | - |
dc.contributor.author | Toth, Miklos | - |
dc.contributor.author | Artigas Pérez, Francesc | - |
dc.date.accessioned | 2020-06-09T19:21:15Z | - |
dc.date.available | 2020-06-09T19:21:15Z | - |
dc.date.issued | 2010-02-17 | - |
dc.identifier.issn | 1461-1457 | - |
dc.identifier.uri | http://hdl.handle.net/2445/164959 | - |
dc.description.abstract | Atypical antipsychotic drugs (APDs) increase dopamine (DA) release in prefrontal cortex (PFC), an effect probably mediated by the direct or indirect activation of the 5-HT(1A) receptor (5-HT(1A)R). Given the very low in-vitro affinity of most APDs for 5-HT(1A)Rs and the large co-expression of 5-HT(1A)Rs and 5-HT(2A) receptors (5-HT(2A)Rs) in the PFC, this effect might result from the imbalance of 5-HT(1A)R and 5-HT(2A)R activation after blockade of these receptors by APDs, for which they show high affinity. Here we tested this hypothesis by examining the dependence of the APD-induced DA release in medial PFC (mPFC) on each receptor by using in-vivo microdialysis in wild-type (WT) and 5-HT(1A)R and 5-HT(2A)R knockout (KO) mice. Local APDs (clozapine, olanzapine, risperidone) administered by reverse dialysis induced a dose-dependent increase in mPFC DA output equally in WT and 5-HT(2A)R KO mice whereas the DA increase was absent in 5-HT(1A)R KO mice. To examine the relative contribution of both receptors to the clozapine-induced DA release in rat mPFC, we silenced G-protein-coupled receptors (GPCRs) in vivo with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) while 5-HT(1A)Rs or 5-HT(2A)/2CRs in the mPFC were selectively protected with the respective antagonists WAY-100635 or ritanserin. The inactivation of GPCRs while preserving ∼70% of 5-HT(2A)/(2C)Rs prevented the clozapine-induced DA rise in mPFC. In contrast, clozapine increased DA in mPFC of EEDQ-treated rats whose 5-HT(1A)Rs were protected (∼50% of control rats). These results indicate that (1) 5-HT(1A)Rs are necessary for the APDs-induced elevation in cortical DA transmission, and (2) this effect does not require 5-HT(2A)R blockade by APDs. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1017/S146114571000009X | - |
dc.relation.ispartof | International Journal of Neuropsychopharmacology, 2010, vol. 13, num. 10, p. 1299-1314 | - |
dc.relation.uri | https://doi.org/10.1017/S146114571000009X | - |
dc.rights | (c) CINP (Collegium Internationale Neuro-Psychopharmacologicum) , 2010 | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Antipsicòtics | - |
dc.subject.classification | Dopamina | - |
dc.subject.classification | Escorça frontal | - |
dc.subject.classification | Receptors de serotonina | - |
dc.subject.other | Antipsychotic drugs | - |
dc.subject.other | Dopamine | - |
dc.subject.other | Prefrontal cortex | - |
dc.subject.other | Serotonin receptors | - |
dc.title | Dopamine Release Induced by Atypical Antipsychotics in Prefrontal Cortex Requires 5-HT(1A) Receptors but Not 5-HT(2A) Receptors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 683441 | - |
dc.date.updated | 2020-06-09T19:21:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 20158933 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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683441.pdf | 550.88 kB | Adobe PDF | View/Open |
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