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Title: Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients
Author: Ruiz de Porras, Vicenç
Bystrup, Sara
Cabrero de las Heras, Sara
Musulén, Eva
Palomero, Luis
Alonso Aguado, Maria Henar
Nieto, Rocio
Arango, Diego
Moreno Aguado, Víctor
Queralt, Cristina
Manzano, José Luis
Layos, Laura
Bugés, Cristina
Martinez Balibrea, Eva
Keywords: Càncer colorectal
Marcadors bioquímics
Colorectal cancer
Biochemical markers
Issue Date: 11-Oct-2019
Publisher: MDPI
Abstract: In recent years, an increasing number of studies have shown that elevated expression of cyclin dependent kinase (Cdk5) contributes to the oncogenic initiation and progression of many types of cancers. In this study, we investigated the expression pattern of Cdk5 in colorectal cancer (CRC) cell lines and in a large number of tumor samples in order to evaluate its relevance in this pathogenesis and possible use as a prognostic marker. We found that Cdk5 is highly expressed and activated in CRC cell lines and that silencing of the kinase decreases their migration ability. In tumor tissues, Cdk5 is overexpressed compared to normal tissues due to a copy number gain. In patients with localized disease, we found that high Cdk5 levels correlate with poor prognosis, while in the metastatic setting, this was only the case for patients receiving an oxaliplatin-based treatment. When exploring the Cdk5 levels in the consensus molecular subtypes (CMS), we found the lowest levels in subtype 1, where high Cdk5 again was associated with a poorer prognosis. In conclusion, we confirm that Cdk5 is involved in CRC and disease progression and that it could serve as a prognostic and predictive biomarker in this disease.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2019, vol. 11, num. 10, p. 1540
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ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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