Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/165173
Title: | Calcium regulates HCC proliferation as well as EGFR recycling/degradation and could be a new therapeutic target in HCC |
Author: | Modica, Teresa Maria Elisa Dituri, Francesco Mancarella, Serena Pisano, Claudio Fabregat Romero, Isabel Giannelli, Gianluigi |
Keywords: | Calci Cèl·lules Fetge Proliferació cel·lular Ions Calcium Cells Liver Cell proliferation Ions |
Issue Date: | 18-Oct-2019 |
Publisher: | MDPI |
Abstract: | Calcium is the most abundant element in the human body. Its role is essential in physiological and biochemical processes such as signal transduction from outside to inside the cell between the cells of an organ, as well as the release of neurotransmitters from neurons, muscle contraction, fertilization, bone building, and blood clotting. As a result, intra- and extracellular calcium levels are tightly regulated by the body. The liver is the most specialized organ of the body, as its functions, carried out by hepatocytes, are strongly governed by calcium ions. In this work, we analyze the role of calcium in human hepatoma (HCC) cell lines harboring a wild type form of the Epidermal Growth Factor Receptor (EGFR), particularly its role in proliferation and in EGFR downmodulation. Our results highlight that calcium is involved in the proliferative capability of HCC cells, as its subtraction is responsible for EGFR degradation by proteasome machinery and, as a consequence, for EGFR intracellular signaling downregulation. However, calcium-regulated EGFR signaling is cell line-dependent. In cells responding weakly to the epidermal growth factor (EGF), calcium seems to have an opposite effect on EGFR internalization/degradation mechanisms. These results suggest that besides EGFR, calcium could be a new therapeutic target in HCC. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers11101588 |
It is part of: | Cancers, 2019, vol. 11, num. 10, p. 1588 |
URI: | http://hdl.handle.net/2445/165173 |
Related resource: | https://doi.org/10.3390/cancers11101588 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
694689.pdf | 17.44 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License