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Title: Stereoselective titanium-mediated aldol reactions of a chiral lactate-derived ethyl ketone with ketones
Author: Alcoberro, S.
Gómez-Palomino, A.
Solà, R.
Romea, Pedro
Urpí Tubella, Fèlix
Font Bardia, Ma. Mercedes
Keywords: Cetones
Reaccions d'addició
Compostos orgànics
Acetoacetat d'etil
Addition reactions
Organic compounds
Ethyl acetate
Issue Date: 17-Jan-2014
Publisher: American Chemical Society
Abstract: Aldol reactions of titanium enolates of lactate-derived ethyl ketone 1 with other ketones proceed in a very efficient and stereocontrolled manner provided that a further equivalent of TiCl4 is added to the reacting mixture. The scope of these reactions encompasses simple ketones such as acetone or cyclohexanone as well as other ketones that contain potential chelating groups such as pyruvate esters or α- and β-hydroxy ketones.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2014, vol. 16, num. 2, p. 584-587
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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