Please use this identifier to cite or link to this item:
Title: Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil
Author: Prohens López, Rafael
Barbas Cañero, Rafael
Portell Bueso, Anna
Font Bardia, Ma. Mercedes
Alcobé i Ollé, Xavier
Puigjaner Vallet, Ma. Cristina
Keywords: Estructura cristal·lina (Sòlids)
Medicaments antivírics
Layer structure (Solids)
Antiviral agents
Issue Date: 2015
Publisher: American Chemical Society
Abstract: The solid state of adefovir dipivoxil (AD) has been revisited. In the present article we extend the knowledge about the solid state of this pharmaceutical prodrug. The stability landscape of the amorphous form with respect to the anhydrous and hydrate crystalline forms has been studied, and the use of an antiplasticizing agent to increase its Tg is described. The crystal structure of the elusive anhydrous form I has been determined from laboratory powder X-ray diffraction data by means of direct space methods using the computing program FOX. In addition, three new isostructural solvates of AD (methanol, ethylenglycol, and methylethylketone) have been discovered and structurally characterized by single cristal X-ray diffraction.
Note: Versió postprint del document publicat a:
It is part of: Crystal Growth & Design, 2015, vol. 15, num. 1, p. 475-484
Related resource:
ISSN: 1528-7483
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

Files in This Item:
File Description SizeFormat 
693072.pdf2.03 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.