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http://hdl.handle.net/2445/165288
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DC Field | Value | Language |
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dc.contributor.author | Prohens López, Rafael | - |
dc.contributor.author | Barbas Cañero, Rafael | - |
dc.contributor.author | Portell Bueso, Anna | - |
dc.contributor.author | Font Bardia, Ma. Mercedes | - |
dc.contributor.author | Alcobé i Ollé, Xavier | - |
dc.contributor.author | Puigjaner Vallet, Ma. Cristina | - |
dc.date.accessioned | 2020-06-12T07:17:10Z | - |
dc.date.available | 2020-06-12T07:17:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1528-7483 | - |
dc.identifier.uri | http://hdl.handle.net/2445/165288 | - |
dc.description.abstract | The solid state of adefovir dipivoxil (AD) has been revisited. In the present article we extend the knowledge about the solid state of this pharmaceutical prodrug. The stability landscape of the amorphous form with respect to the anhydrous and hydrate crystalline forms has been studied, and the use of an antiplasticizing agent to increase its Tg is described. The crystal structure of the elusive anhydrous form I has been determined from laboratory powder X-ray diffraction data by means of direct space methods using the computing program FOX. In addition, three new isostructural solvates of AD (methanol, ethylenglycol, and methylethylketone) have been discovered and structurally characterized by single cristal X-ray diffraction. | - |
dc.format.extent | 30 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/cg501542h | - |
dc.relation.ispartof | Crystal Growth & Design, 2015, vol. 15, num. 1, p. 475-484 | - |
dc.relation.uri | https://doi.org/10.1021/cg501542h | - |
dc.rights | (c) American Chemical Society , 2015 | - |
dc.source | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) | - |
dc.subject.classification | Estructura cristal·lina (Sòlids) | - |
dc.subject.classification | Medicaments antivírics | - |
dc.subject.other | Layer structure (Solids) | - |
dc.subject.other | Antiviral agents | - |
dc.title | Expanding the Crystal Form Landscape of the Antiviral Drug Adefovir Dipivoxil | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 693072 | - |
dc.date.updated | 2020-06-12T07:17:10Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
Files in This Item:
File | Description | Size | Format | |
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693072.pdf | 2.03 MB | Adobe PDF | View/Open |
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