Please use this identifier to cite or link to this item:
Title: Developmental effects and genotoxicity of ten water disinfection by-products in zebrafish
Author: Teixidó Condomines, Elisabet
Piqué Benages, Maria Esther
González-Linares, J. (Javier)
Llobet Mallafré, Joan M. (Joan Maria)
Gómez Catalán, Jesús
Keywords: Depuració de l'aigua
Productes derivats
Peix zebra
Water purification
Human abnormalities
Zebra danio
Issue Date: Mar-2015
Publisher: IWA Publishing
Abstract: Disinfection by-products are contaminants produced during drinking water disinfection. Several DBPs have been implicated in a variety of toxic effects, mainly carcinogenic and genotoxic effects. Moreover, DBPs exposure has also been associated with an increased risk of developmental effects. In this study, the developmental toxicity and genotoxicity of 10 DBPs (4 trihalomethanes [THMs], 5 haloacetic acids [HAAs] and sodium bromate) in the zebrafish embryo model were evaluated. Embryos exposed for 72 hours were observed for different endpoints such as growth, hatching success, malformations and lethality. THMs exposure resulted in adverse developmental effects and a significant reduced tail length. Two HAAs, tribromoacetic acid and dichloroacetic acid, along with sodium bromate were found to cause a significant increase in malformation rate. Chloroform,chlorodibromomethane and sodium bromate produced a weak induction of DNA damage to whole embryos. However, developmental effects occurred at a range of concentrations (20 100 μg/mL)several orders of magnitude above the levels that can be attained in fetal blood in humans exposed to chlorinated water. In conclusion, the teratogenic and genotoxic activity observed by some DBPs in zebrafish reinforce the view that there is a weak capacity of disinfection products to cause developmental effects at environmentally relevant concentrations.
Note: Versió postprint del document publicat a:
It is part of: Journal Of Water And Health, 2015, vol. 13, num. 1, p. 54-66
Related resource:
ISSN: 1477-8920
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
642104.pdf1.15 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.