Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorQuintanilla, Isabel-
dc.contributor.authorLópez-Cerón Pinilla, María-
dc.contributor.authorJimeno, Mireya-
dc.contributor.authorCuatrecasas Freixas, Miriam-
dc.contributor.authorZabalza, Michel-
dc.contributor.authorMoreira, Leticia-
dc.contributor.authorAlonso-Espinaco, Virginia-
dc.contributor.authorRodríguez de Miguel, Cristina-
dc.contributor.authorMuñoz, Jenifer-
dc.contributor.authorCastellví Bel, Sergi-
dc.contributor.authorLlach Vila, Josep-
dc.contributor.authorCastells Garangou, Antoni-
dc.contributor.authorBalaguer Prunés, Francesc-
dc.contributor.authorCamps, Jordi-
dc.contributor.authorPellisé Urquiza, Maria-
dc.description.abstractNTRODUCTION: Over the past 20 years, aberrant crypt foci (ACF) have emerged as potential precursors and biomarkers for colorectal cancer (CRC). However, data regarding their molecular pathogenesis, as well as their endoscopic and histological identification, remain inconsistent. METHODS: A wide cohort of ACF from 100 control subjects and 100 case patients, including patients with adenoma and CRC, were characterized for endoscopic, morphologic, and molecular features. RESULTS: We observed that among all the endoscopic features evaluated, only the number of large ACF correlated with CRC risk (P = 0.003), whereas the histological classification, as assessed by 2 different pathologists, was inconsistent and did not differ between control and case patients. Moreover, only a few APC and BRAF mutations and no microsatellite instability were detected in our samples. KRAS mutations were detected in 16.3% of ACF samples, which also exhibited increased MGMT hypermethylation. However, none of those events were found to be predictive of CRC risk. DISCUSSION: Although ACF might be preneoplastic lesions of the colon, they are not suitable biomarkers for assessing CRC progression.-
dc.format.extent8 p.-
dc.publisherWolters Kluwer Health-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofClinical and Translational Gastroenterology, 2019, vol. 10, num. 6, p. 00047-
dc.rightscc-by-nc-nd (c) Quintanilla, Isabel et al., 2019-
dc.subject.classificationCàncer colorectal-
dc.subject.otherColorectal cancer-
dc.titleRectal Aberrant Crypt Foci in Humans Are Not Surrogate Markers for Colorectal Cancer Risk-
Appears in Collections:Articles publicats en revistes (Fonaments Clínics)

Files in This Item:
File Description SizeFormat 
695490.pdf417.96 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons