Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/165679
Title: The integrin-mediated adhesion complex: cooption of signaling systems at the dawn of Metazoa
Author: Sebé Pedrós, Arnau
Ruiz Trillo, Iñaki
Keywords: Genòmica
Evolució (Biologia)
Metazous
Genomics
Evolution (Biology)
Metazoa
Issue Date: 2010
Publisher: Landes Bioscience
Abstract: The integrin-mediated adhesion machinery is the primary cell-matrix adhesion mechanism in Metazoa. The integrin adhesion complex, which modulates important aspects of the cell physiology, is composed of integrins (α and β subunits) and several scaffolding and signaling proteins. Integrins appeared to be absent in all non-metazoan eukaryotes so far analyzed, including fungi, plants, and choanoflagellates, the sister-group to Metazoa. Thus, integrins and, therefore, the integrin-mediated adhesion and signaling mechanism was considered a metazoan innovation. Recently, a broad comparative genomic analysis including new genome data from several unicellular organisms closely related to fungi and metazoans shattered previous views. The integrin adhesion and signaling complex is not specific to Metazoa, but rather it is present in apusozoans and holozoan protists. Thus, this important signaling and adhesion system predated the origin of Fungi and Metazoa, and was subsequently lost in fungi and choanoflagellates. This finding suggests that cooption played a more important role in the origin of Meta-zoa than previously believed. Here, we hypothesize that the integrin adhesome was ancestrally involved in signaling.
Note: Reproducció del document publicat a: https://doi.org/10.4161/cib.3.5.12603
It is part of: Communicative & Integrative Biology, 2010, vol. 3, num. 5, p. 475-477
URI: http://hdl.handle.net/2445/165679
Related resource: https://doi.org/10.4161/cib.3.5.12603
ISSN: 1942-0889
Appears in Collections:Articles publicats en revistes (Institut de Recerca de la Biodiversitat (IRBio))
Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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