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Title: Comparative assessment of the sensitivity of fish early-life stage, daphnia and algae to the chronic ecotoxicity of xenobiotics - perspectives for alternatives to animal testing
Author: Teixidó Condomines, Elisabet
Leuthold, David
Crozé, Noémi de
Léonard, Marc
Scholz, Stefan
Keywords: Experimentació animal
Tests de toxicitat
Animal experimentation
Toxicity testing
Issue Date: 18-Dec-2019
Publisher: Wiley
Abstract: No-observed-effect concentrations (NOECs) are used in environmental hazard classification and labeling of chemicals and their environmental risk assessment. They are typically obtained using standard tests such as the fish early-life stage (FELS) toxicity test, the chronic Daphnia reproduction test, and the algae growth inhibition test. Given the demand to replace and reduce animal tests, we explored the impact of the FELS toxicity test on the determination of effect concentrations by comparing the FELS toxicity test and the Daphnia and algae acute or chronic toxicity tests. Lowest-observed-effect concentrations (LOECs) were used instead of NOECs for better comparison with median lethal or effect concentration data. A database of FELS toxicity data for 223 compounds was established. Corresponding Daphnia and algae toxicity tests were identified using established databases (US Environmental Protection Agency ECOTOX, Organisation for Economic Co-operation and Development QSAR Toolbox, eChemPortal, EnviroTox, and OpenFoodTox). Approximately 9.5% of the investigated compounds showed a 10-fold higher sensitivity with the FELS toxicity test in comparison with the lowest effect concentrations obtained with any of the other tests. Some of these compounds have been known or considered as endocrine disrupting, or are other non-narcotic chemicals, indicating that the higher sensitivity in the FELS toxicity test is related to a specific mechanism of action. Targeting these mechanisms by alternative test systems or endpoints, using fish embryos for instance, may allow reduction or replacement of the FELS toxicity test or may allow us to prioritize compounds for conduction of the FELS toxicity test.
Note: Versió postprint del document publicat a:
It is part of: Environmental Toxicology and Chemistry, 2019, vol. 39, num. 1, p. 30-41
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ISSN: 0730-7268
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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