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Title: The Impact of Culturing the Organ Preservation Fluid on Solid Organ Transplantation: A Prospective Multicenter Cohort Study. Open Forum Infect Dis
Author: Oriol, I.
Fernández Sabé, Núria
Càmara, J.
Berbel, Dámaris
Ballesteros, M. A.
Escudero, R.
López Medrano, Francisco
Linares, Laura
Len, Óscar
Silva, J. T.
Oliver, E.
Soldevila, L.
Pérez Recio, S.
Guillem, LL.
Camprubí, D.
Lladó Garriga, Laura
Manonelles, Anna
González Costello, J.
Domínguez, M. A.
Fariñas, M. C.
Lavid, N.
González Rico, C.
Garcia Cuello, L.
Arnaiz de Las Revillas, F.
Fortun, J.
Aguado, José María
Jimenez Romero, C.
Bodro, M.
Almela, M. (Manel)
Paredes, D.
Moreno, A.
Pérez Cameo, C.
Muñoz Sanz, A.
Blanco Fernández, G.
Cabo González, J. A.
García López, J. L.
Nuño, E.
Carratalà, Jordi
Keywords: Trasplantament d'òrgans
Anàlisi de regressió
Transplantation of organs
Regression analysis
Issue Date: 2019
Publisher: Oxford University Press
Abstract: Background: We analyzed the prevalence, etiology, and risk factors of culture-positive preservation fluid and their impact on the management of solid organ transplant recipients. Methods: From July 2015 to March 2017, 622 episodes of adult solid organ transplants at 7 university hospitals in Spain were prospectively included in the study. Results: The prevalence of culture-positive preservation fluid was 62.5% (389/622). Nevertheless, in only 25.2% (98/389) of the cases were the isolates considered "high risk" for pathogenicity. After applying a multivariate regression analysis, advanced donor age was the main associated factor for having culture-positive preservation fluid for high-risk microorganisms. Preemptive antibiotic therapy was given to 19.8% (77/389) of the cases. The incidence rate of preservation fluid-related infection was 1.3% (5 recipients); none of these patients had received preemptive therapy. Solid organ transplant (SOT) recipients with high-risk culture-positive preservation fluid receiving preemptive antibiotic therapy presented both a lower cumulative incidence of infection and a lower rate of acute rejection and graft loss compared with those who did not have high-risk culture-positive preservation fluid. After adjusting for age, sex, type of transplant, and prior graft rejection, preemptive antibiotic therapy remained a significant protective factor for 90-day infection. Conclusions: The routine culture of preservation fluid may be considered a tool that provides information about the contamination of the transplanted organ. Preemptive therapy for SOT recipients with high-risk culture-positive preservation fluid may be useful to avoid preservation fluid-related infections and improve the outcomes of infection, graft loss, and graft rejection in transplant patients.
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It is part of: Open Forum Infectious Diseases, 2019, vol. 26, num. 6, p. 180
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ISSN: 2328-8957
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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