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http://hdl.handle.net/2445/166002
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DC Field | Value | Language |
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dc.contributor.author | Hidalgo-Tenorio, Carmen | - |
dc.contributor.author | Vinuesa, David | - |
dc.contributor.author | Plata, Antonio | - |
dc.contributor.author | Martín-Dávila, Pilar | - |
dc.contributor.author | Iftimie, Simona | - |
dc.contributor.author | Sequera, Sergio | - |
dc.contributor.author | Loeches, Belén | - |
dc.contributor.author | Lopez-Cortés, Luis Eduardo | - |
dc.contributor.author | Fariñas, Mari Carmen | - |
dc.contributor.author | Fernández-Roldan, Concepción | - |
dc.contributor.author | Javier-Martinez, Rosario | - |
dc.contributor.author | Muñoz, Patricia | - |
dc.contributor.author | Arenas-Miras, Maria del Mar | - |
dc.contributor.author | Martínez-Marcos, Francisco Javier | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Herrero, Carmen | - |
dc.contributor.author | Bereciartua, Elena | - |
dc.contributor.author | De, Jesus, Samantha E. | - |
dc.contributor.author | Pasquau, Juan | - |
dc.date.accessioned | 2020-06-17T10:41:56Z | - |
dc.date.available | 2020-06-17T10:41:56Z | - |
dc.date.issued | 2019-10-19 | - |
dc.identifier.issn | 1476-0711 | - |
dc.identifier.uri | http://hdl.handle.net/2445/166002 | - |
dc.description.abstract | Objectives: To analyse the effectiveness of dalbavancin (DBV) in clinical practice as consolidation therapy in patients with bloodstream infection (BSI) and/or infective endocarditis (IE) produced by gram-positive cocci (GPC), as well as its safety and pharmacoeconomic impact. Methods: A multicentre, observational and retrospective study was conducted of hospitalised patients with IE and/or BSI produced by GPC who received at least one dose of DBV. Clinical response was assessed during hospitalization, at 3 months and at 1 year. Results: Eighty-three patients with median age of 73 years were enrolled; 73.5% were male; 59.04% had BSI and 49.04% IE (44.04% prosthetic valve IE, 32.4% native IE, 23.5% pacemaker lead). The most frequently isolated microorganism was Staphylococcus aureus in BSI (49%) and coagulase-negative staphylococci in IE (44.1%). All patients with IE were clinically cured in hospital; at 12 months, there was 2.9% loss to follow-up, 8.8% mortality unrelated to IE, and 2.9% therapeutic failure rate. The percentage effectiveness of DBV to treat IE was 96.7%. The clinical cure rate for BSI was 100% during hospital stay and at 3 months; there were no recurrences or deaths during the follow-up. No patient discontinued treatment for adverse events. The saving in hospital stay was 636 days for BSI (315,424.20 ) and 557 days for IE (283,187.45 ). Conclusions: DBV is an effective consolidation antibiotic therapy in clinically stabilized patients with IE and/or BSI. It proved to be a cost-effective treatment, reducing the hospital stay, thanks to the pharmacokinetic/pharmacodynamic profile of this drug. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12941-019-0329-6 | - |
dc.relation.ispartof | Annals of Clinical Microbiology and Antimicrobials, 2019, vol. 18, p. 30 | - |
dc.relation.uri | https://doi.org/10.1186/s12941-019-0329-6 | - |
dc.rights | cc-by (c) Hidalgo-Tenorio, Carmen et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Endocarditis | - |
dc.subject.classification | Farmacocinètica | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.other | Endocarditis | - |
dc.subject.other | Pharmacokinetics | - |
dc.subject.other | Antibiotics | - |
dc.title | DALBACEN cohort: dalbavancin as consolidation therapy in patients with endocarditis and/or bloodstream infection produced by gram-positive cocci | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 693671 | - |
dc.date.updated | 2020-06-17T10:41:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31629409 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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