Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/166307
Title: Cationic surfactants: self-Assembly, structure-activity correlation and their biological applications
Author: Zakharova, Lucia Ya.
Pashirova, Tatiana N.
Doktorovova, Slamovira
Fernandes, Ana R.
Sánchez-López, E. (Elena)
Silva, Amélia M.
Souto, Selma B.
Souto, Eliana B.
Keywords: Farmacologia
Sistemes d'alliberament de medicaments
Agents tensioactius
Solubilitat dels medicaments
Nanoestructures
QSAR (Bioquímica)
Cations
Pharmacology
Drug delivery systems
Surface active agents
Drug solubility
Nanostructures
QSAR (Biochemistry
Cations
Issue Date: 6-Nov-2019
Publisher: MDPI
Abstract: The development of biotechnological protocols based on cationic surfactants is a modern trend focusing on the fabrication of antimicrobial and bioimaging agents, supramolecular catalysts, stabilizers of nanoparticles, and especially drug and gene nanocarriers. The main emphasis given to the design of novel ecologically friendly and biocompatible cationic surfactants makes it possible to avoid the drawbacks of nanoformulations preventing their entry to clinical trials. To solve the problem of toxicity various ways are proposed, including the use of mixed composition with nontoxic nonionic surfactants and/or hydrotropic agents, design of amphiphilic compounds bearing natural or cleavable fragments. Essential advantages of cationic surfactants are the structural diversity of their head groups allowing of chemical modification and introduction of desirable moiety to answer the green chemistry criteria. The latter can be exemplified by the design of novel families of ecological friendly cleavable surfactants, with improved biodegradability, amphiphiles with natural fragments, and geminis with low aggregation threshold. Importantly, the development of amphiphilic nanocarriers for drug delivery allows understanding the correlation between the chemical structure of surfactants, their aggregation behavior, and their functional activity. This review focuses on several aspects related to the synthesis of innovative cationic surfactants and their broad biological applications including antimicrobial activity, solubilization of hydrophobic drugs, complexation with DNA, and catalytic effect toward important biochemical reaction
Note: Reproducció del document publicat a: https://doi.org/10.3390/ijms20225534
It is part of: International Journal of Molecular Sciences, 2019, vol. 20, num. 22, p. 5534
URI: http://hdl.handle.net/2445/166307
Related resource: https://doi.org/10.3390/ijms20225534
ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Files in This Item:
File Description SizeFormat 
701301.pdf1.19 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons