Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/167084
Title: Integrating the roles of liver x receptors in inflammation and infection: mechanisms and outcomes
Author: Glaría Percaz, Estíbaliz
Letelier, Nicole A.
Valledor Fernández, Annabel
Keywords: Receptors nuclears (Bioquímica)
Edema
Infeccions
Nuclear receptors (Biochemistry)
Edema
Infections
Issue Date: 1-Aug-2020
Publisher: Elsevier
Abstract: Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of metabolic and anti-inflammatory actions that result in the modulation of immune responses and in the amelioration of inflammatory disorders. In addition, LXR agonists modulate the metabolism of infected cells and limit the infectivity and/or growth of several pathogens. This review gives an overview of the recent advances in understanding the complexity of the mechanisms through which the LXR pathway controls inflammation and host-cell pathogen interaction.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.coph.2020.05.001
It is part of: Current Opinion In Pharmacology, 2020, vol. 53, p. 55-65
URI: http://hdl.handle.net/2445/167084
Related resource: https://doi.org/10.1016/j.coph.2020.05.001
ISSN: 1471-4892
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Files in This Item:
File Description SizeFormat 
702198.pdf1.71 MBAdobe PDFView/Open    Request a copy


Embargat   Document embargat fins el 1-8-2021


This item is licensed under a Creative Commons License Creative Commons