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http://hdl.handle.net/2445/167278| Title: | Electric field causes volumetric changes in the human brain |
| Author: | Argyelan, Miklos Oltedal, Leif Deng, Zhi-De Wade, Benjamin Bikson, Marom Joanlanne, Andrea Sanghani, Sohag Bartsch, Hauke Cano Català, Marta Dale, Anders M. Dannlowski, Udo Dols, Annemiek Enneking, Verena Espinoza, Randall Kessler, Ute Narr, Katherine Oedegaard, Ketil J. Oudega, Mardien L. Redlich, Ronny Stek, Max L. Takamiya, Akihiro Emsell, Louise Bouckaert, Filip Sienaert, Pascal Pujol, Jesús Tendolkar, Indira Van Eijndhoven, Philip Petrides, Georgios Malhotra, Anil K. Abbott, Christopher |
| Keywords: | Teràpia de xoc Camps elèctrics Cervell Shock therapy Electric fields Brain |
| Issue Date: | 23-Oct-2019 |
| Publisher: | eLife Sciences Publications |
| Abstract: | Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion. |
| Note: | Reproducció del document publicat a: https://doi.org/10.7554/eLife.49115 |
| It is part of: | Elife, 2019, Vol. 8, p. e49115 |
| URI: | http://hdl.handle.net/2445/167278 |
| Related resource: | https://doi.org/10.7554/eLife.49115 |
| Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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|---|---|---|---|---|
| ArgyelanM.pdf | 1.32 MB | Adobe PDF | View/Open |
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