Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/167300
Title: Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells
Author: Soto Cerrato, Vanessa
Manuel-Manresa, Pilar
Hernando, Elsa
Calabuig-Fariñas, Silvia
Martínez-Romero, Alicia
Fernández Dueñas, Víctor
Sahlholm, Kristoffer
Knöpfel, Thomas
García Valverde, María
Rodilla Martín, Ananda Marina
Jantus-Lewintre, Eloisa
Farràs, Rosa
Ciruela Alférez, Francisco
Pérez Tomás, Ricardo E.
Quesada, Roberto
Keywords: Apoptosi
Fisiologia
Cèl·lules mare
Patologia
Apoptosis
Physiology
Stem cells
Pathology
Issue Date: 23-Dec-2015
Publisher: American Chemical Society
Abstract: Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation.
Note: Versió postprint del document publicat a: https://doi.org/10.1021/jacs.5b09970
It is part of: Journal of the American Chemical Society, 2015, vol. 137, num. 50, p. 15892-15898
URI: http://hdl.handle.net/2445/167300
Related resource: https://doi.org/10.1021/jacs.5b09970
ISSN: 0002-7863
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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