Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/167300
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DC Field | Value | Language |
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dc.contributor.author | Soto Cerrato, Vanessa | - |
dc.contributor.author | Manuel-Manresa, Pilar | - |
dc.contributor.author | Hernando, Elsa | - |
dc.contributor.author | Calabuig-Fariñas, Silvia | - |
dc.contributor.author | Martínez-Romero, Alicia | - |
dc.contributor.author | Fernández Dueñas, Víctor | - |
dc.contributor.author | Sahlholm, Kristoffer | - |
dc.contributor.author | Knöpfel, Thomas | - |
dc.contributor.author | García Valverde, María | - |
dc.contributor.author | Rodilla Martín, Ananda Marina | - |
dc.contributor.author | Jantus Lewintre, Eloisa | - |
dc.contributor.author | Farràs, Rosa | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.contributor.author | Pérez Tomás, Ricardo E. | - |
dc.contributor.author | Quesada, Roberto | - |
dc.date.accessioned | 2020-07-02T09:22:50Z | - |
dc.date.available | 2020-07-02T09:22:50Z | - |
dc.date.issued | 2015-12-23 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/2445/167300 | - |
dc.description.abstract | Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/jacs.5b09970 | - |
dc.relation.ispartof | Journal of the American Chemical Society, 2015, vol. 137, num. 50, p. 15892-15898 | - |
dc.relation.uri | https://doi.org/10.1021/jacs.5b09970 | - |
dc.rights | (c) American Chemical Society , 2015 | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Apoptosi | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.classification | Patologia | - |
dc.subject.other | Apoptosis | - |
dc.subject.other | Physiology | - |
dc.subject.other | Stem cells | - |
dc.subject.other | Pathology | - |
dc.title | Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 656454 | - |
dc.date.updated | 2020-07-02T09:22:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26632983 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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656454.pdf | 766 kB | Adobe PDF | View/Open |
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