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Title: Recent advances and perspectives in the design and development of polymyxins
Author: Rabanal Anglada, Francesc
Cajal Visa, Yolanda
Keywords: Medicaments antibacterians
Estructura molecular
Antibacterial agents
Molecular structure
Issue Date: 2017
Publisher: Royal Society of Chemistry
Abstract: The rise of bacterial pathogens with acquired resistance to almost all available antibiotics is becoming a serious public health issue. Polymyxins, antibiotics that were mostly abandoned a few decades ago because of toxicity concerns, are ultimately considered as a last-line therapy to treat infections caused by multi-drug resistant Gram-negative bacteria. This review surveys the progress in understanding polymyxin structure, chemistry, mechanisms of antibacterial activity and nephrotoxicity, biomarkers, synergy and combination with other antimicrobial agents and antibiofilm properties. An update of recent efforts in the design and development of a new generation of polymyxin drugs is also discussed. A novel approach considering the modification of the scaffold of polymyxins to integrate metabolism and detoxification issues into the drug design process is a promising new line to potentially prevent accumulation in kidney and reduce nephrotoxicity
Note: Versió postprint del document publicat a:
It is part of: Natural Product Reports, 2017, vol. 34, num. 7, p. 886-908
Related resource:
ISSN: 0265-0568
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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