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Title: Molecular markers for prostate cancer in formalin-fixed paraffin-embedded tissues
Author: Sequeiros, Tamara
Garcia, Marta
Montes, Melania
Olivan Riera, Mireia
Rigau, Marina
Colás, Eva
Torres, Inés de
Morote, Juan
Reventós Puigjaner, Jaume
Doll, Andreas
Keywords: Indicadors biològics
Micro RNAs
Càncer de pròstata
Indicators (Biology)
Prostate cancer
Issue Date: 25-Nov-2013
Publisher: Hindawi
Abstract: Prostate cancer (PCa) is the most frequently diagnosed type of cancer in developed countries. The decisive method of diagnosis is based on the results of biopsies, morphologically evaluated to determine the presence or absence of cancer. Although this approach leads to a confident diagnosis in most cases, it can be improved by using the molecular markers present in the tissue. Both miRNAs and proteins are considered excellent candidates for biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues, due to their stability over long periods of time. In the last few years, a concerted effort has been made to develop the necessary tools for their reliable measurement in these types of samples. Furthermore, the use of these kinds of markers may also help in establishing tumor grade and aggressiveness, as well as predicting the possible outcomes in each particular case for the different treatments available. This would aid clinicians in the decision-making process. In this review, we attempt to summarize and discuss the potential use of microRNA and protein profiles in FFPE tissue samples as markers to better predict PCa diagnosis, progression, and response to therapy.
Note: Reproducció del document publicat a:
It is part of: BioMed Research International, 2013, vol. 2013, p. 283635
Related resource:
ISSN: 2314-6133
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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