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Title: Low-dose statin treatment increases prostate cancer aggressiveness
Author: Caro Maldonado, Alfredo
Camacho, Laura
Zabala Letona, Amaia
Torrano, Verónica
Fernández Ruiz, Sonia
Zamacola-Bascaran, Kepa
Arreal, Leire
Valcárcel-Jiménez, Lorea
Martín-Martín, Natalia
Flores, Juana María
Cortazar, Ana Rosa
Zúñiga García, Patricia
Arruabarrena-Aristorena, Amaia
Guillaumond, Fabienne
Cabrera, Diana
Falcón Pérez, Juan M.
Aransay, Ana M.
Gomez-Muñoz, Antonio
Olivan Riera, Mireia
Morote, Juan
Carracedo, Arkaitz
Keywords: Colesterol
Càncer de pròstata
Prostate cancer
Issue Date: 5-Jan-2018
Publisher: Impact Journals
Abstract: Prostate cancer is diagnosed late in life, when co-morbidities are frequent. Among them, hypertension, hypercholesterolemia, diabetes or metabolic syndrome exhibit an elevated incidence. In turn, prostate cancer patients frequently undergo chronic pharmacological treatments that could alter disease initiation, progression and therapy response. Here we show that treatment with anti-cholesterolemic drugs, statins, at doses achieved in patients, enhance the pro-tumorigenic activity of obesogenic diets. In addition, the use of a mouse model of prostate cancer and human prostate cancer xenografts revealed that in vivo simvastatin administration alone increases prostate cancer aggressiveness. In vitro cell line systems supported the notion that this phenomenon occurs, at least in part, through the direct action on cancer cells of low doses of statins, in range of what is observed in human plasma. In sum, our results reveal a prostate cancer experimental system where statins exhibit an undesirable effect, and warrant further research to address the relevance and implications of this observation in human prostate cancer.
Note: Reproducció del document publicat a:
It is part of: Oncotarget, 2018, vol. 9, num. 2, p. 1494-1504
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ISSN: 1949-2553
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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