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DC Field | Value | Language |
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dc.contributor.author | Rapado González, Óscar | - |
dc.contributor.author | Majem, Blanca | - |
dc.contributor.author | Álvarez Castro, Ana | - |
dc.contributor.author | Díaz Peña, Roberto | - |
dc.contributor.author | Abalo, Alicia | - |
dc.contributor.author | Suárez Cabrera, Leticia | - |
dc.contributor.author | Gil Moreno, Antonio | - |
dc.contributor.author | Santamaría, Anna | - |
dc.contributor.author | López López, Rafael | - |
dc.contributor.author | Muinelo Romay, Laura | - |
dc.contributor.author | Suarez Cunqueiro, María Mercedes | - |
dc.date.accessioned | 2020-07-07T15:30:50Z | - |
dc.date.available | 2020-07-07T15:30:50Z | - |
dc.date.issued | 2019-12-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/168023 | - |
dc.description.abstract | Salivary microRNAs (miRNAs) are of high interest as diagnostic biomarkers for non-oral cancer. However, little is known about their value for colorectal cancer (CRC) detection. Our study aims to characterize salivary miRNAs in order to identify non-invasive markers for CRC diagnosis. The screening of 754 miRNAs was performed in saliva samples from 14 CRC and 10 healthy controls. The differential expressed miRNAs were validated by RT-qPCR in 51 CRC, 19 adenomas and 37 healthy controls. Receiver operating characteristic (ROC) curves and logistic regression models were performed to analyze the clinical value of these miRNAs. Twenty-two salivary miRNAs were significantly deregulated in CRC patients vs. healthy individuals (p < 0.05) in the discovery phase. From those, five upregulated miRNAs (miR-186-5p, miR-29a-3p, miR-29c-3p, miR-766-3p, and miR-491-5p) were confirmed to be significantly higher in the CRC vs. healthy group (p < 0.05). This five-miRNA signature showed diagnostic value (72% sensitivity, 66.67% specificity, AUC = 0.754) to detect CRC, which was even higher in combination with carcinoembryonic antigen (CEA) levels. Overall, after the first global characterization of salivary miRNAs in CRC, a five-miRNA panel was identified as a promising tool to diagnose this malignancy, representing a novel approach to detect cancer-associated epigenetic alterations using a non-invasive strategy. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Mdpi | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm8122029 | - |
dc.relation.ispartof | Journal Of Clinical Medicine, 2019-12-01, Vol. 8, Issue 12 | - |
dc.relation.uri | https://doi.org/10.3390/jcm8122029 | - |
dc.rights | cc by (c) Rapado González, Óscar et al.,2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Biochemical markers | - |
dc.title | A Novel Saliva-Based miRNA Signature for Colorectal Cancer Diagnosis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2020-07-06T08:26:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31757017 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Rapado-GonzalezO.pdf | 2.2 MB | Adobe PDF | View/Open |
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