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Title: A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus
Author: Farmakis, Dimitrios
Agostoni, Piergiuseppe
Baholli, Loant
Bautin, Andrei
Comín Colet, Josep
Crespo Leiro, María G.
Fedele, Francesco
García Pinilla, José Manuel
Giannakoulas, George
Grigioni, Francesco
Gruchala, Marcin
Gustafsson, Finn
Harjola, Veli Pekka
Hasin, Tal
Herpain, Antoine
Iliodromitis, Efstathios K.
Karason, Kristjan
Kivikko, Matti
Liaudet, Lucas
Ljubas Macek, Jana
Marini, Marco
Masip, Josep (Masip i Utset)
Mebazaa, Alexandre
Nikolaou, Maria
Ostadal, Petr
Poder, Pentti
Pollesello, Piero
Polyzogopoulou, Eftihia
Polzl, Gerhard
Tschope, Carsten
Varpula, Marjun
Von Lewinski, Dirk
Vrtovec, Bojan
Yilmaz, Mehmet Birhan
Zima, Endre
Parissis, John
Keywords: Insuficiència cardíaca
Malalties cardiovasculars
Heart failure
Cardiovascular diseases
Issue Date: 15-Dec-2019
Publisher: Elsevier Ireland Ltd
Abstract: Inotropes aim at increasing cardiac output by enhancing cardiac contractility. They constitute the third pharmacological pillar in the treatment of patients with decompensated heart failure, the other two being diuretics and vasodilators. Three classes of parenterally administered inotropes are currently indicated for decompensated heart failure, (i) the beta adrenergic agonists, including dopamine and dobutamine and also the catecholamines epinephrine and norepinephrine, (ii) the phosphodiesterase III inhibitor milrinone and (iii) the calcium sensitizer levosimendan. These three families of drugs share some pharmacologic traits, but differ profoundly in many of their pleiotropic effects. Identifying the patients in need of inotropic support and selecting the proper inotrope in each case remain challenging. The present consensus, derived by a panel meeting of experts from 21 countries, aims at addressing this very issue in the setting of both acute and advanced heart failure. (C) 2019 The Authors. Published by Elsevier B.V.
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It is part of: International Journal Of Cardiology, 2019-12-15, Vol. 297, P. 83-90
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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