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http://hdl.handle.net/2445/168548
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DC Field | Value | Language |
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dc.contributor.author | Muzzio, María L. | - |
dc.contributor.author | Kabakian, María L. | - |
dc.contributor.author | Morosán-Allo, Yanina | - |
dc.contributor.author | Ferrari, Silvia | - |
dc.contributor.author | Fallahi, Poupak | - |
dc.contributor.author | Fernández, Jorgelina | - |
dc.contributor.author | Santucci de Magistris, Maria | - |
dc.contributor.author | Andrés Lacueva, Ma. Cristina | - |
dc.contributor.author | Antonelli, Alessandro | - |
dc.contributor.author | Brenta, Gabriela | - |
dc.contributor.author | Meroño, Tomás | - |
dc.date.accessioned | 2020-07-14T08:21:56Z | - |
dc.date.available | 2021-03-24T06:10:23Z | - |
dc.date.issued | 2020-03-24 | - |
dc.identifier.issn | 0939-4753 | - |
dc.identifier.uri | http://hdl.handle.net/2445/168548 | - |
dc.description.abstract | Background and aims Glomerular hyperfiltration (GH) is proposed as one of the earliest events in obesity (OB)-associated renal disease. Children with GH and type-1 diabetes showed increased chemokine levels. Chemokine associations with glomerular filtration rate (GFR) and metabolic features in prepubertal children with overweight (OW)/OB are unknown. Methods and results Cross-sectional study. 75 prepubertal children (aged: 9.0 ± 1.7 years) with OW/OB were studied. Clinical and metabolic characteristics (including non-esterified fatty acids, NEFA) and GFR (combined Zappitelli equation) were assessed. GH was defined as GFR >135 ml/min.1.73 m2. Serum levels of regulated on activation, normal T cell expressed and secreted (RANTES)/CCL5, interleukin-8 (IL-8)/CXCL8 and monokine-induced by interferon-γ (MIG)/CXCL9 were measured by ELISA. Age- and sex-adjusted correlations and differences were tested. 48% of the cohort was female and 13% were OW, 54% OB and 33% severe OB. Prepubertal children with GH showed lower z-BMI (−12%), NEFA (−26%) and uric acid (−22%) than those without GH (all p < 0.05). Similarly to high sensitivity C-reactive protein (hsCRP), there were no differences in serum chemokines between children with GH or not (all p > 0.05). Adjusted correlations were significant for RANTES and z-BMI (r = 0.26; p < 0.05) and for MIG with z-BMI (r = −0.26; p < 0.05) and with NEFA (r = 0.27; p < 0.05). Conclusion GH was not associated with higher chemokine levels in prepubertal children with OW/OB. Decreased rather than elevated GFR values were correlated with obesity and worse metabolic profiles. Chemokines levels in children with severe OB suggest a regulation of the immune response. Follow-up studies are needed to address the clinical implications of these findings. Keywords ObesityChildrenChemokinesHyperfiltrationRenal disease | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.numecd.2020.03.012 | - |
dc.relation.ispartof | Nutrition Metabolism and Cardiovascular Diseases, 2020 | - |
dc.relation.uri | https://doi.org/10.1016/j.numecd.2020.03.012 | - |
dc.rights | cc-by-nc-nd (c) Elsevier B.V., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Obesitat en els infants | - |
dc.subject.classification | Malalties del ronyó | - |
dc.subject.other | Obesity in children | - |
dc.subject.other | Kidney diseases | - |
dc.title | Association of glomerular hyperfiltration with serum chemokine levels and metabolic features in prepubertal children with overweight/obesity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 700049 | - |
dc.date.updated | 2020-07-14T08:21:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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