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Title: Toxicity study in blood and tumor cells of laser produced medicines for application in fabrics
Author: Morán Badenas, María del Carmen
Tozar, Tatiana
Simon, Agota
Dinache, Andra
Smarandache, Adriana
Andrei, Ionut Relu
Boni, Mihai
Pascu, Mihail Lucian
Cirisano, Francesca
Ferrari, Michele
Keywords: Cèl·lules
Citotoxicitat per mediació cel·lular
Cell-mediated cytotoxicity
Issue Date: 1-Jan-2016
Publisher: Elsevier B.V.
Abstract: Phenothiazine derivatives are non-antibiotics with antimicrobial, fungistatic and fungicidal effects. We exposed to a high energy UV laser beam phenothiazines solutions in water at 20mg/mL concentration to increase antibacterial activity of resulting mixtures. Compared to previous results obtained on bacteria, more research is needed about UV laser irradiated phenothiazines applications on cancer cell cultures to evidence possible anticancerous properties. Evaluation of the safety of the newly obtained photoproducts in view of use on humans is also needed. Due to expensive animal testing in toxicology and pressure from general public and governments to develop alternatives to in vivo testing, in vitro cell-based models are attractive for preliminary testing of new materials. Cytotoxicity screening reported here shows that laser irradiated (4h exposure time length) chlorpromazine and promazine are more efficient against some cell cultures. Interaction of laser irradiated phenothiazines with fabrics show that promethazine and chlorpromazine have improved wetting properties. Correlation of these two groups of properties shows that chlorpromazine appears to be more recommended for applications on tissues using fabrics as transport vectors. The reported results concern stability study of phenothiazines water solutions to know the time limits within which they are stable and may be used. Keywords: Culture cells; Fabrics; Hemolysis; In vitro cytotoxicity; Laser; Phenothiazines.
Note: Versió postprint del document publicat a:
It is part of: Colloids and Surfaces B-Biointerfaces, 2016, vol. 137, p. 91-103
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ISSN: 0927-7765
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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