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Title: HERC ubiquitin ligases in cancer
Author: Sala Gaston, Joan
Martinez-Martinez, Arturo
Pedrazza, Leonardo
Lorenzo-Martín, L. Francisco
Caloto, Rubén
Bustelo, Xosé R.
Ventura Pujol, Francesc
Rosa López, José Luis
Keywords: Genomes
Proteïnes supressores de tumors
Tumor suppressor protein
Issue Date: 22-Jun-2020
Publisher: MDPI
Abstract: HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3-HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type. We include a discussion of both the molecular mechanisms involved and the potential therapeutic strategies.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2020, vol. 12, num. 6, p. E1653
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ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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