Please use this identifier to cite or link to this item:
|Title:||Human secretory IgM emerges from plasma cells clonally related to gut memory B cells and targets highly diverse commensals|
Grasset, Emilie K.
van Zelm, Menno C.
Albero González, Raquel
Mercadé Gil, M. Elena
|Abstract:||Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM+ plasma cells (PCs) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM+ B cells disseminated throughout the intestine but rare in systemic lymphoid organs. In addition to sharing a gut-specific gene signature with memory IgA+ B cells, memory IgM+ B cells were related to some IgA+ clonotypes and switched to IgA in response to T cell-independent or T cell-dependent signals. These signals induced abundant IgM which, together with SIgM from clonally affiliated PCs, recognized mucus-embedded commensals. Bacteria recognized by human SIgM were dually coated by SIgA and showed increased richness and diversity compared to IgA-only-coated or uncoated bacteria. Thus, SIgM may emerge from pre-existing memory rather than newly activated naive IgM+ B cells and could help SIgA to anchor highly diverse commensal communities to mucus.|
|Note:||Versió postprint del document publicat a: https://doi.org/10.1016/j.immuni.2017.06.013|
|It is part of:||Immunity, 2017, vol. 47, num. 1, p. 118-134|
|Appears in Collections:||Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)|
This item is licensed under a Creative Commons License