Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/169432
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPenon Esteva, Oriol-
dc.contributor.authorPatiño, Tania-
dc.contributor.authorBarrios, Lleonard-
dc.contributor.authorNogués, Carme-
dc.contributor.authorAmabilino, David B.-
dc.contributor.authorWurst, Klaus-
dc.contributor.authorPérez García, M. Lluïsa (Maria Lluïsa)-
dc.date.accessioned2020-07-24T07:04:17Z-
dc.date.available2020-07-24T07:04:17Z-
dc.date.issued2015-
dc.identifier.issn2191-1363-
dc.identifier.urihttp://hdl.handle.net/2445/169432-
dc.description.abstractA potential new photosensitizer based on a dissymmetric porphyrin derivative bearing a thiol group was synthesized. 5-[4-(11-Mercaptoundecyloxy)-phenyl-10,15,20-triphenylporphyrin (PR-SH) was used to functionalize gold nanoparticles in order to obtain a potential drug delivery system. Water-soluble multifunctional gold nanoparticles GNP-PR/PEG were prepared using the Brust-Schiffrin methodology, by immobilization of both a thiolated polyethylene glycol (PEG) and the porphyrin thiol compound (PR-SH). The nanoparticles were fully characterized by transmission electron microscopy and 1H nuclear magnetic resonance spectroscopy, UV/Vis absorption spectroscopy, and X-ray photoelectron spectroscopy. Furthermore, the ability of GNP-PR/PEGs to induce singlet oxygen production was analyzed to demonstrate the activity of the photosensitizer. Cytotoxicity experiments showed the nanoparticles are nontoxic. Finally, cellular uptake experiments demonstrated that the functionalized gold nanoparticles are internalized. Therefore, this colloid can be considered to be a novel nanosystem that could potentially be suitable as an intracellular drug delivery system of photosensitizers for photodynamic therapy. Keywords: drug delivery, gold nanoparticles, photodynamic therapy, photosensitizers, porphyrins-
dc.format.extent10 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH Verlag-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1002/open.201402092-
dc.relation.ispartofChemistryOpen, 2015, vol. 4, p. 127-136-
dc.relation.urihttps://doi.org/10.1002/open.201402092-
dc.rightscc-by-nc-nd (c) Penon Esteva, Oriol et al., 2015-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es-
dc.subject.classificationAdministració de medicaments-
dc.subject.classificationNanopartícules-
dc.subject.classificationOr-
dc.subject.classificationNanotecnologia-
dc.subject.otherAdministration of drugs-
dc.subject.otherNanoparticles-
dc.subject.otherGold-
dc.subject.otherNanotechnology-
dc.titleA New Porphyrin for the Preparation of Functionalized Water-Soluble Gold Nanoparticles with Low Intrinsic Toxicity-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec659755-
dc.date.updated2020-07-24T07:04:17Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
659755.pdf2.33 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons