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Title: New iron(II) cyclopentadienyl derivative complexes: synthesis and antitumor activity against human leukemia cancer cells
Author: Valente, A.
Santos, A.M.
Côrte-Real, L.
Robalo, M.P.
Moreno Martínez, Virtudes
Font Bardia, Ma. Mercedes
Calvet Pallàs, Maria Teresa
Lorenzo, J.
Garcia, M.E.
Keywords: Compostos organometàl·lics
Cèl·lules canceroses
Organometallic compounds
Cancer cells
Issue Date: 15-Apr-2014
Publisher: Elsevier B.V.
Abstract: A new family of 'FeII(h5-C5H5)' half sandwich compounds bearing a N-heteroaromatic ligand coordinated to the iron center by a nitrile functional group has been synthesized and fully characterized by NMR and UVeVis spectroscopy. X-ray analysis of single crystal was achieved for complexes 1 and 3, which crystallized in the monoclinic P21/c and monoclinic P21/n space groups, respectively. Studies of interaction of these five new complexes with plasmid pBR322 DNA by atomic force microscopy showed very strong and different types of interaction. Antiproliferative tests were examined on human leukemia cancer cells (HL-60) using the MTT assay, and the IC50 values revealed excellent antiproliferative activity compared to cisplatin.
Note: Versió postprint del document publicat a:
It is part of: Journal of Organometallic Chemistry, 2014, vol. 756, p. 52-60
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ISSN: 0022-328X
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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