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Title: Inhibitors of lipogenic enzymes as a potential therapy against cancer
Author: Montesdeoca, Nicolás
López, Marta
Ariza Piquer, Xavier
Herrero Rodríguez, Laura
Makowski, Kamil
Keywords: Enzims
Metabolisme dels lípids
Medicaments antineoplàstics
Lipid metabolism
Antineoplastic agents
Issue Date: 2020
Publisher: The Federation of American Society of Experimental Biology
Abstract: Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the increase in energy demand, cell division, and growth and successfully adapt to challenging environments. Fatty acid synthesis is therefore commonly enhanced in many cancer cell lines. Thus, relevant efforts are being made by the scientific community to inhibit the enzymes involved in lipid metabolism to disrupt cancer cell proliferation. We review the rapidly expanding body of inhibitors that target lipid metabolism, their side effects, and current status in clinical trials as potential therapeutic approaches against cancer. We focus on their molecular, biochemical and structural properties, selectivity and effectiveness and discuss their potential role as antitumor drugs. Keywords: cancer drugs; lipid metabolism; lipogenic enzyme inhibitors.
Note: Versió preprint del document publicat a:
It is part of: The FASEB Journal , 2020, vol. 34, num. 9, p. 11355-11381
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ISSN: 0892-6638
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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