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http://hdl.handle.net/2445/170234
Title: | Inhibitors of lipogenic enzymes as a potential therapy against cancer |
Author: | Montesdeoca, Nicolás López, Marta Ariza Piquer, Xavier Herrero Rodríguez, Laura Makowski, Kamil |
Keywords: | Enzims Metabolisme dels lípids Medicaments antineoplàstics Enzymes Lipid metabolism Antineoplastic agents |
Issue Date: | 2020 |
Publisher: | The Federation of American Society of Experimental Biology |
Abstract: | Cancer cells rely on several metabolic pathways such as lipid metabolism to meet the increase in energy demand, cell division, and growth and successfully adapt to challenging environments. Fatty acid synthesis is therefore commonly enhanced in many cancer cell lines. Thus, relevant efforts are being made by the scientific community to inhibit the enzymes involved in lipid metabolism to disrupt cancer cell proliferation. We review the rapidly expanding body of inhibitors that target lipid metabolism, their side effects, and current status in clinical trials as potential therapeutic approaches against cancer. We focus on their molecular, biochemical and structural properties, selectivity and effectiveness and discuss their potential role as antitumor drugs. Keywords: cancer drugs; lipid metabolism; lipogenic enzyme inhibitors. |
Note: | Versió preprint del document publicat a: https://doi.org/10.1096/fj.202000705R |
It is part of: | The FASEB Journal , 2020, vol. 34, num. 9, p. 11355-11381 |
URI: | http://hdl.handle.net/2445/170234 |
Related resource: | https://doi.org/10.1096/fj.202000705R |
ISSN: | 0892-6638 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
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702851.pdf | 256.44 kB | Adobe PDF | View/Open |
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