Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/170325
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dc.contributor.authorGandioso, Albert-
dc.contributor.authorEl Fakiri, Mohamed-
dc.contributor.authorRovira, Anna-
dc.contributor.authorMarchán Sancho, Vicente-
dc.date.accessioned2020-09-08T13:25:51Z-
dc.date.available2020-09-08T13:25:51Z-
dc.date.issued2020-08-07-
dc.identifier.issn2046-2069-
dc.identifier.urihttp://hdl.handle.net/2445/170325-
dc.description.abstractWe describe a novel transition metal-free method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using readily available ethyl bromodifluoroacetate as a fluorine source. The formation of N-difluoromethylated pyridines involves a two-step process in which N-alkylation by ethyl bromodifluoroacetate is followed by in situ hydrolysis of the ester and decarboxylation. Besides optimizing the N-difluoromethylation conditions and assessing the influence of steric and electronic effects on the outcome of the reaction, we have synthesized the N-difluoromethylated analogues of two fluorophores and demonstrated that their spectroscopic properties can be improved through replacement of N-CH3 group by N-CF2H.-
dc.format.extent6 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherRoyal Society of Chemistry-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1039/d0ra06322c-
dc.relation.ispartofRSC Advances, 2020, vol. 10, p. 29829-29834-
dc.relation.urihttps://doi.org/10.1039/d0ra06322c-
dc.rightscc-by (c) López-Corrales, Marta et al., 2020-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.subject.classificationSíntesi orgànica-
dc.subject.classificationCompostos de metalls de transició-
dc.subject.otherOrganic synthesis-
dc.subject.otherTransition metal compounds-
dc.titleA simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec703114-
dc.date.updated2020-09-08T13:25:51Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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