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Title: Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model
Author: Companys Alemany, Júlia
Cozar, Mónica
Grinberg Vaisman, Daniel Raúl
Vilageliu i Arqués, Lluïsa
Codony Gisbert, Sandra
Vázquez Cruz, Santiago
Pallàs i Llibería, Mercè, 1964-
Griñán Ferré, Christian
Keywords: Malalties de Niemann-Pick
Trastorns del metabolisme
Niemann-Pick diseases
Disorders of metabolism
Issue Date: Sep-2020
Abstract: Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids and where the autophagy-lysosome system and inflammatory processes are implicated in the pathogenesis of the disease. We follow a novel approach to deal with NPC disease, by modulating key features of the disease such as inflammation and autophagy, through inhibition of soluble epoxide hydrolase (sEH).
Note: Reproducció del document publicat a:
It is part of: Pòster presentat a: 33rd European College of Neuropsychopharmacology (ECNP) Congress. 12-15 September 2020
Appears in Collections:Comunicacions a congressos (Institut de Biomedicina (IBUB))
Comunicacions a congressos (Farmacologia, Toxicologia i Química Terapèutica)
Comunicacions a congressos (Genètica, Microbiologia i Estadística)
Comunicacions a congressos (Institut de Neurociències (UBNeuro))

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