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Title: | Pharmacological inhibition of soluble epoxide hydrolase protects cognitive impairment in a Niemann-Pick mice model |
Author: | Companys Alemany, Júlia Cozar, Mónica Grinberg Vaisman, Daniel Raúl Vilageliu i Arqués, Lluïsa Codony Gisbert, Sandra Vázquez Cruz, Santiago Pallàs i Llibería, Mercè, 1964- Griñán Ferré, Christian |
Keywords: | Malalties de Niemann-Pick Trastorns del metabolisme Cognició Niemann-Pick diseases Disorders of metabolism Cognition |
Issue Date: | Sep-2020 |
Abstract: | Niemann-Pick type C (NPC) disease is a childhood autosomal recessive inherited rare neurodegenerative disease characterized by accumulation of cholesterol and glycosphingolipids and where the autophagy-lysosome system and inflammatory processes are implicated in the pathogenesis of the disease. We follow a novel approach to deal with NPC disease, by modulating key features of the disease such as inflammation and autophagy, through inhibition of soluble epoxide hydrolase (sEH). |
Note: | Reproducció del document publicat a: https://ecnp33-ecnp.ipostersessions.com/default.aspx?s=D7-E7-A0-5B-12-E1-80-A8-97-EE-37-30-9D-AC-5E-71&guestview=true |
It is part of: | Pòster presentat a: 33rd European College of Neuropsychopharmacology (ECNP) Congress. 12-15 September 2020 |
URI: | http://hdl.handle.net/2445/170656 |
Appears in Collections: | Comunicacions a congressos (Institut de Biomedicina (IBUB)) Comunicacions a congressos (Farmacologia, Toxicologia i Química Terapèutica) Comunicacions a congressos (Genètica, Microbiologia i Estadística) Comunicacions a congressos (Institut de Neurociències (UBNeuro)) |
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