Please use this identifier to cite or link to this item:
Title: Human Papillomavirus and factors associated with recurrence in sinonasal inverted papillomas from Poland and Spain
Author: Fulla, M.
Szafarowski, Tomasz
Frias Gomez, Jon
Quirós, B.
Clavero, Omar
Gomà, M.
Pavón Ribas, Miquel Àngel
Jurek-Matusiak, O.
Lares, Henry R.
Maños Pujol, Manuel
Alemany i Vilches, Laia
Mena Cervigón, Marisa
Gonzalez Compta, Xavier
Keywords: Papil·lomavirus
Factors de risc en les malalties
Risk factors in diseases
Issue Date: 8-Jan-2020
Publisher: Springer Nature
Abstract: Sinonasal inverted papilloma (SNIP) is a benign but locally aggressive tumor that has a tendency for recurrence and malignant transformation. The role of human papillomavirus (HPV) in SNIP is controversial. To determine the HPV-DNA prevalence and type distribution in SNIP in two different geographic areas and assess the association between SNIP recurrence and HPV infection, as well as additional potential etiologic factors. Two retrospective cohorts of SNIP patients from Poland and Spain were evaluated. Demographic, tobacco/alcohol use, clinical, and follow-up data were collected. All samples were subject to histopathologic evaluation, DNA quality control, and HPV-DNA detection by PCR. HPV-DNA positive samples and a random sample of HPV-DNA negative cases were further subject to p16INK4a analysis. Proportional-hazards models were used to evaluate the risk of recurrence by selected variables. Seventy-nine SNIP patients (46 from Spain diagnosed between 1995 and 2014, and 33 from Poland diagnosed between 2012 and 2017) were included in the study. HPV-DNA was detected in four patients (5.1%), two from each region, and all four were positive for the HPV11 subtype. Seventeen patients (21.5%) experienced recurrence, with a median time to recurrence of 14 months. No association was identified between lesional HPV-DNA positivity, toxic habits, Krouse stage, or malignant transformation and a higher risk of recurrence. The low prevalence of HPV-DNA in SNIPs suggests that HPV is not a main etiology for development of these lesions. With a lack of association between the evaluated factors and recurrence, further research with larger number of patients and additional biomarkers is warranted to further understand predisposing risk factors.
Note: Versió postprint del document publicat a:
It is part of: Head and neck pathology , 2020, vol. 14, p. 758-767
Related resource:
ISSN: 1936-055X
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
698665.pdf1.96 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.