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http://hdl.handle.net/2445/171048
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DC Field | Value | Language |
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dc.contributor.author | Galli, Luisa | - |
dc.contributor.author | Crichton, S. | - |
dc.contributor.author | Buzzoni, C. | - |
dc.contributor.author | Goetghebuer, Tessa | - |
dc.contributor.author | Jourdain, G. | - |
dc.contributor.author | Judd, Ali | - |
dc.contributor.author | Klein, N. | - |
dc.contributor.author | José Mellado, M. | - |
dc.contributor.author | Noguera Julian, Antoni | - |
dc.contributor.author | Kahlert, C. | - |
dc.contributor.author | Spoulou, Vana | - |
dc.contributor.author | Scherpbier, H. | - |
dc.contributor.author | Marques, Laura | - |
dc.contributor.author | Collins, Intira J. | - |
dc.contributor.author | Gibb, Diana M. | - |
dc.contributor.author | González Tomé, Maria Isabel | - |
dc.contributor.author | Warszawski, Josiane | - |
dc.contributor.author | Dollfus, C. | - |
dc.contributor.author | Königs, Christoph | - |
dc.contributor.author | Prata, Filipa | - |
dc.contributor.author | Chiappini, Elena | - |
dc.contributor.author | Naver, Lars | - |
dc.contributor.author | Giaquinto, Carlo | - |
dc.contributor.author | Thorne, Claire | - |
dc.contributor.author | Marczynska, Magdalena | - |
dc.contributor.author | Okhonskaia, Liubov | - |
dc.contributor.author | Borkird, T. | - |
dc.contributor.author | Attavinijtrakarn, P. | - |
dc.contributor.author | Malyuta, Ruslan | - |
dc.contributor.author | Volokha, Alla | - |
dc.contributor.author | Ene, Luminita | - |
dc.contributor.author | Goodall, Ruth | - |
dc.date.accessioned | 2020-10-05T15:36:01Z | - |
dc.date.available | 2020-10-05T15:36:01Z | - |
dc.date.issued | 2019-05-16 | - |
dc.identifier.issn | 1464-2662 | - |
dc.identifier.uri | http://hdl.handle.net/2445/171048 | - |
dc.description.abstract | Objectives: The aim of the study was to explore factors associated with CD4 percentage (CD4%) reconstitution following treatment interruptions (TIs) of antiretroviral therapy (ART). Methods: Data from paediatric HIV-infected cohorts across 17 countries in Europe and Thailand were pooled. Children on combination ART (cART; at least three drugs from at least two classes) for > 6 months before TI of ≥ 30 days while aged < 18 years were included. CD4% at restart of ART (r-ART) and in the long term (up to 24 months after r-ART) following the first TI was modelled using asymptotic regression. Results: In 779 children with at least one TI, the median age at first TI was 10.1 [interquartile range (IQR) 6.4, 13.6] years and the mean CD4% was 27.3% [standard deviation (SD) 11.0%]; the median TI duration was 9.0 (IQR 3.5, 22.5) months. In regression analysis, the mean CD4% was 19.2% [95% confidence interval (CI) 18.3, 20.1%] at r-ART, and 27.1% (26.2, 27.9%) in the long term, with half this increase in the first 6 months. r-ART and long-term CD4% values were highest in female patients and in children aged < 3 years at the start of TI. Long-term CD4% was highest in those with a TI lasting 1 to <3 months, those with r-ART after year 2000 and those with a CD4% nadir ≥ 25% (all P < 0.001). The effect of CD4% nadir during the TI differed significantly (P = 0.038) by viral suppression at the start of the TI; in children with CD4% nadir < 15% during TI, recovery was better in those virally suppressed prior to the TI; viral suppression was not associated with recovery in children with CD4% nadir ≥ 25%. Conclusions: After restart of ART following TI, most children reconstituted well immunologically. Nevertheless, several factors predicted better immunological reconstitution, including younger age and higher nadir CD4% during TI. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1111/hiv.12745 | - |
dc.relation.ispartof | HIV Medicine, 2019, vol. 20, num. 7, p. 456-472 | - |
dc.relation.uri | https://doi.org/10.1111/hiv.12745 | - |
dc.rights | cc-by-nc-nd (c) Galli et. al. , 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.classification | Pediatria | - |
dc.subject.classification | Limitació de l'esforç terapèutic | - |
dc.subject.other | Antiretroviral agents | - |
dc.subject.other | Pediatrics | - |
dc.subject.other | Withholding treatment | - |
dc.title | CD4 recovery following antiretroviral treatment interruptions in children and adolescents with HIV infection in Europe and Thailand | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 690083 | - |
dc.date.updated | 2020-10-05T15:36:01Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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690083.pdf | 658.92 kB | Adobe PDF | View/Open |
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