Please use this identifier to cite or link to this item:
Title: POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas
Author: Calvete, Oriol
Garcia Pavia, Pablo
Dominguez, Fernando
Mosteiro, Lluc
Pérez Cabornero, Lucía
Cantalapiedra, Diego
Zorio, Esther
Ramón y Cajal, Teresa
Crespo Leiro, María G.
Teulé-Vega, Àlex
Lázaro García, Conxi
Morente, Manuel M.
Urioste, Miguel
Benitez, Javier
Keywords: Angiogènesi
Issue Date: 17-Jan-2019
Publisher: Wiley
Abstract: Background: Mutations in the POT1 gene explain abnormally long telomeres and multiple tumors including cardiac angiosarcomas (CAS). However, the link between long telomeres and tumorigenesis is poorly understood. Methods and Results: Here, we have studied the somatic landscape of 3 different angiosarcoma patients with mutations in the POT1 gene to further investigate this tumorigenesis process. In addition, the genetic landscape of 7 CAS patients without mutations in the POT1 gene has been studied. Patients with CAS and nonfunctional POT1 did not repress ATR (ataxia telangiectasia RAD3-related)-dependent DNA damage signaling and showed a constitutive increase of cell cycle arrest and somatic activating mutations in the VEGF (vascular endothelial growth factor)/angiogenesis pathway (KDR gene). The same observation was made in POT1 mutation carriers with tumors different from CAS and also in CAS patients without mutations in the POT1 gene but with mutations in other genes involved in DNA damage signaling. Conclusions: Inhibition of POT1 function and damage-response malfunction activated DNA damage signaling and increased cell cycle arrest as well as interfered with apoptosis, which would permit acquisition of somatic mutations in the VEGF/angiogenesis pathway that drives tumor formation. Therapies based on the inhibition of damage signaling in asymptomatic carriers may diminish defects on cell cycle arrest and thus prevent the apoptosis deregulation that leads to the acquisition of driver mutations.
Note: Reproducció del document publicat a:
It is part of: Journal of the American Heart Association, 2019, vol. 8, num. 18
Related resource:
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
CalveteO.pdf2.41 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons