Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171263
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dc.contributor.authorJiang, Xia-
dc.contributor.authorFinucane, Hilary K.-
dc.contributor.authorSchumacher, Fredrick R.-
dc.contributor.authorSchmit, Stephanie L.-
dc.contributor.authorTyrer, Jonathan P.-
dc.contributor.authorHan, Younghun-
dc.contributor.authorMichailidou, Kyriaki-
dc.contributor.authorLesseur, Corina-
dc.contributor.authorKuchenbaecker, Karoline B.-
dc.contributor.authorDennis, Joe-
dc.contributor.authorConti, David V.-
dc.contributor.authorChanock, Stephen J.-
dc.contributor.authorRossing, Mary Anne-
dc.contributor.authorTeare, M. Dawn-
dc.contributor.authorJames, Paul-
dc.contributor.authorBerndt, Sonja I.-
dc.contributor.authorCampbell, Ian-
dc.contributor.authorFortner, Renée T.-
dc.contributor.authorLee, Eunjung-
dc.contributor.authorChang-Claude, Jenny-
dc.contributor.authorChristiani, David C.-
dc.contributor.authorPashayan, Nora-
dc.contributor.authorMay, Taymaa-
dc.contributor.authorGronwald, Jacek-
dc.contributor.authorPrice, Alkes L.-
dc.contributor.authorCasey, Graham-
dc.contributor.authorKoutros, Stella-
dc.contributor.authorDuell, Eric J.-
dc.contributor.authorChenevix-Trench, Georgia-
dc.contributor.authorNeuhausen, Susan L.-
dc.contributor.authorHong, Yun-Chul-
dc.contributor.authorParsons, Michael T.-
dc.contributor.authorTung, Nadine-
dc.contributor.authorClaessens, Frank-
dc.contributor.authorMargolin, Sara-
dc.contributor.authorSchleutker, Johanna-
dc.contributor.authorPark, Jong Y.-
dc.contributor.authorKnight, Julia A.-
dc.contributor.authorCruz Correa, Marcia-
dc.contributor.authorWiklund, Fredrik-
dc.contributor.authorBandera, Elisa V.-
dc.contributor.authorSiegel, Erin M.-
dc.contributor.authorLe, Nhu D.-
dc.contributor.authorTaylor, Jack A.-
dc.contributor.authorDonovan, Jenny L.-
dc.contributor.authorLandi, Maria Teresa-
dc.contributor.authorAldrich, Melinda C.-
dc.contributor.authorVelez Edwards, Digna R.-
dc.contributor.authorEaston, Douglas F.-
dc.contributor.authorBerchuck, Andrew-
dc.contributor.authorDevilee, Peter-
dc.contributor.authorHeitz, Florian-
dc.contributor.authorHopper, John L.-
dc.contributor.authorHunter, David J.-
dc.contributor.authorPeters, Ulrike-
dc.contributor.authorAlbanes, Jeroen R.-
dc.contributor.authorWoll, Penella-
dc.contributor.authorGarcía-Sáenz, José A.-
dc.contributor.authorLiloglou, Triantafillos-
dc.contributor.authorPhipps, Amanda I.-
dc.contributor.authorCybulski, Cezary-
dc.contributor.authorLi, Christopher I.-
dc.contributor.authorLazarus, Philip-
dc.contributor.authorSawyer, Elinor J.-
dc.contributor.authorMeindl, Alfons-
dc.contributor.authorPeters, Wilbert H. M.-
dc.contributor.authorGoode, Ellen L.-
dc.contributor.authorBarkardottir, Rosa B.-
dc.contributor.authorBien, Stephanie A.-
dc.contributor.authorUlrich, Cornelia M.-
dc.contributor.authorBrunnström, Hans-
dc.contributor.authorGoldgar, David E.-
dc.contributor.authorFletcher, Olivia-
dc.contributor.authorMoysich, Kirsten B.-
dc.contributor.authorHøgdall, Estrid-
dc.contributor.authorGallinger, Steven J.-
dc.contributor.authorChen, Chu-
dc.contributor.authorElías Aguado-Barrera, Miguel-
dc.contributor.authorImyanitov, Evgeny N.-
dc.contributor.authorClements, Judith-
dc.contributor.authorMacInnis, Robert J.-
dc.contributor.authorIdos, Gregory-
dc.contributor.authorDaly, Mary B.-
dc.contributor.authorAnton-Culver, Hoda-
dc.contributor.authorWinqvist, Robert-
dc.contributor.authorDiergaarde, Brenda-
dc.contributor.authorCollée, J. Margriet-
dc.contributor.authorBjørge, Line-
dc.contributor.authorUsmani, Nawaid-
dc.contributor.authordeFazio, Anna-
dc.contributor.authorCzene, Kamila-
dc.contributor.authorGanz, Patricia A.-
dc.contributor.authorCampa, Daniele-
dc.contributor.authorLindström, Sara-
dc.contributor.authorZiogas, Argyrios-
dc.contributor.authorPlaseska-Karanfilska, Dijana-
dc.contributor.authorGago-Dominguez, Manuela-
dc.contributor.authorBlomqvist, Carl-
dc.contributor.authorHillemanns, Peter-
dc.contributor.authorTravis, Ruth C.-
dc.contributor.authorGoodman, Marc T.-
dc.contributor.authorKelemen, Linda E.-
dc.contributor.authorVan Nieuwenhuysen, Els-
dc.contributor.authorSchmidt, Marjanka K.-
dc.contributor.authorFigueiredo, Jane C.-
dc.contributor.authorNussbaum, Robert L.-
dc.contributor.authorZorn, Kristin K.-
dc.contributor.authorArnold, Susanne M.-
dc.contributor.authorRadice, Paolo-
dc.contributor.authorFostira, Florentia-
dc.contributor.authorWichmann, H-Erich-
dc.contributor.authorGaudet, Mia M.-
dc.contributor.authorBurwinkel, Barbara-
dc.contributor.authorThibodeau, Stephen N.-
dc.contributor.authorSaxena, Richa-
dc.contributor.authorHulick, Peter J.-
dc.contributor.authorWhite, Emily-
dc.contributor.authorTajara, Eloiza H.-
dc.contributor.authorButzow, Ralf-
dc.contributor.authorBeckmann, Matthias W.-
dc.contributor.authorShen, Hongbing-
dc.contributor.authorSundfeldt, Karin-
dc.contributor.authorLester, Jenny-
dc.contributor.authorDwek, Miriam-
dc.contributor.authorGrankvist, Kjell-
dc.contributor.authorSetiawan, V. Wendy-
dc.contributor.authorBrook, Mark N.-
dc.contributor.authorRennert, Hedy S.-
dc.contributor.authorLindo, Noralane M.-
dc.contributor.authorLam, Stephan-
dc.contributor.authorSandler, Dale P.-
dc.contributor.authorvan Rensburg, Elizabeth J.-
dc.contributor.authorLevine, Douglas A.-
dc.contributor.authorSutphen, Rebecca-
dc.contributor.authorIsaacs, Claudine-
dc.contributor.authorZheng, Wei-
dc.contributor.authorCampbell, Peter T.-
dc.contributor.authorOlshan, Andrew F.-
dc.contributor.authorModugno, Francesmary-
dc.contributor.authorRamu, Susan J.-
dc.contributor.authorCox, Angela-
dc.contributor.authorWang, Qin-
dc.contributor.authorCarvalho, André L.-
dc.contributor.authorLambrechts, Diether-
dc.contributor.authorAntonenkova, Natalia N.-
dc.contributor.authorAndrew, Angeline S.-
dc.contributor.authorJohansson, Mikael-
dc.contributor.authorJohansson, Mattias-
dc.contributor.authorHerrero, Rolando-
dc.contributor.authorHåkansson, Niclas-
dc.contributor.authorLejbkowicz, Flavio-
dc.contributor.authorMoreno Aguado, Víctor-
dc.contributor.authorGruber, Stephen B.-
dc.contributor.authorGronberg, Henrik-
dc.contributor.authorKristensen, Vessela N.-
dc.contributor.authorSieh, Weiva-
dc.contributor.authorJoshi, Amit D.-
dc.contributor.authorOlah, Edith-
dc.contributor.authorZienolddiny, Shanbeh-
dc.contributor.authorVega, Ana-
dc.contributor.authorHall, Per-
dc.contributor.authorRennert, Gad-
dc.contributor.authorDunning, Alison M.-
dc.contributor.authorOsorio, Ana-
dc.contributor.authorHoffmeister, Michael-
dc.contributor.authorSpurdle, Amanda B.-
dc.contributor.authorMarchand, Loïc Le-
dc.contributor.authorBuchanan, Daniel D.-
dc.contributor.authorHamann, Ute-
dc.contributor.authorCaporaso, Neil E.-
dc.contributor.authorPenney, Kathryn L.-
dc.contributor.authorJenkins, Mattias-
dc.contributor.authorTardón, Adonina-
dc.contributor.authorKupryjanczyk, Jolanta-
dc.contributor.authorKibel, Adam S.-
dc.contributor.authorWeissler, Mark C.-
dc.contributor.authorTerry, Kathryn L.-
dc.contributor.authorNess, Andrew R.-
dc.contributor.authorNevanlinna, Heli-
dc.contributor.authorLiu, Geoffrey-
dc.contributor.authorBarnes, Daniel R.-
dc.contributor.authorMiller, Austin-
dc.contributor.authorTischkowitz, Marc-
dc.contributor.authorMcKay, James D.-
dc.contributor.authorRaskin, Leon-
dc.contributor.authorBojesen, Stig E.-
dc.contributor.authorHaugen, Aage-
dc.contributor.authorNielsen, Finn Cilius-
dc.contributor.authorSwerdlow, Anthony J.-
dc.contributor.authorMulligan, Anna Marie-
dc.contributor.authorWeitzel, Jeffrey N.-
dc.contributor.authorGodwin, Andrew K.-
dc.contributor.authorLacko, Martin-
dc.contributor.authorKhusnutdinova, Elza-
dc.contributor.authorFranceschi, Silvia-
dc.contributor.authorBrunet, Joan-
dc.contributor.authorMilne, Roger L.-
dc.contributor.authorSimard, Jacques-
dc.contributor.authorHamilton, Robert J.-
dc.contributor.authorKühl, Tabea-
dc.contributor.authorMuir, Kenneth-
dc.contributor.authorWest, Catharine M. L.-
dc.contributor.authorLesse, Davor-
dc.contributor.authorKjaer, Susanne K.-
dc.contributor.authorBickeböller, Heike-
dc.contributor.authorMucci, Lorelei-
dc.contributor.authorJakubowska, Anna-
dc.contributor.authorNikitina-Zake, Liene-
dc.contributor.authorLoupakis, Fotios-
dc.contributor.authorWu, Anna H.-
dc.contributor.authorRisch, Angela-
dc.contributor.authorMaier, Christiane-
dc.contributor.authorKhaw, Kay-Tee-
dc.contributor.authorSouthey, Melissa C.-
dc.contributor.authorTownsend, Paul A.-
dc.contributor.authorThomas, Duncan-
dc.contributor.authorVachon, Celine M.-
dc.contributor.authorEccles, Diana M.-
dc.contributor.authorKote-Jarai, Zsofia-
dc.contributor.authorHuyghe, Jeroen R.-
dc.contributor.authorHoulston, Richard-
dc.contributor.authorFasching, Peter A.-
dc.contributor.authorKim, Jeri-
dc.contributor.authorProkofyeva, Darya-
dc.contributor.authorGiles, Graham G.-
dc.contributor.authorKarlan, Beth Y.-
dc.contributor.authorAntoniou, Antonis C.-
dc.contributor.authorKiemeney, Lambertus A.-
dc.contributor.authorBogdanova, Natalia V.-
dc.contributor.authorGuénel, Pascal-
dc.contributor.authorBrennan, Paul-
dc.contributor.authorBatra, Jyotsna-
dc.contributor.authorLindblom, Annika-
dc.contributor.authorAmos, Christopher I.-
dc.contributor.authorLeslie, Goska-
dc.contributor.authorThomassen, Mads-
dc.contributor.authorAl Olama, Ali Amin-
dc.contributor.authorPring, Miranda-
dc.contributor.authorBenitez, Javier-
dc.contributor.authorCancel-Tassin, Géraldine-
dc.contributor.authorWoods, Michael-
dc.contributor.authorTworoger, Shelley S.-
dc.contributor.authorNathanson, Katherine L.-
dc.contributor.authorTeixeira, Manuel R.-
dc.contributor.authorSaloustros, Emmanouil-
dc.contributor.authorNewcomb, Polly A.-
dc.contributor.authorCunningham, Julie M.-
dc.contributor.authorJohn, Esther M.-
dc.contributor.authorCouch, Fergus J.-
dc.contributor.authorBolla, Manjeet K.-
dc.contributor.authorGoodman, Gary-
dc.contributor.authorEvans, D. Gareth-
dc.contributor.authorRiggan, Marjorie J.-
dc.contributor.authorKaneva, Radka-
dc.contributor.authorOffit, Kenneth-
dc.contributor.authorWu, Xifeng-
dc.contributor.authorNewcomb, Lisa F.-
dc.contributor.authorStevens, Victoria L.-
dc.contributor.authorSinger, Christian F.-
dc.contributor.authorLane, Jacqueline M.-
dc.contributor.authorLenz, Heinz-Josef-
dc.contributor.authorPhelan, Catherine M.-
dc.contributor.authorEdlund, Christopher K.-
dc.contributor.authorPasaniuc, Bogdan-
dc.contributor.authorPharoah, Paul D. P.-
dc.contributor.authorGayther, Simon A.-
dc.contributor.authorSlattery, Martha L.-
dc.contributor.authorTorres, Diana-
dc.contributor.authorSchabath, Matthew B.-
dc.contributor.authorAndrulis, Irene L.-
dc.contributor.authorKogevinas, Manolis-
dc.contributor.authorBenlloch, Sara-
dc.contributor.authorRuyck, Kim De-
dc.contributor.authorOlsson, Håkan-
dc.contributor.authorArun, Banu K.-
dc.contributor.authorAronson, Kristan J.-
dc.contributor.authorCaligo, Maria A.-
dc.contributor.authorIngles, Sue Ann-
dc.contributor.authorHsu, Li-
dc.contributor.authorRosenstein, Barry S.-
dc.contributor.authorClaes, Kathleen B. M.-
dc.contributor.authorNordestgaard, Børge G.-
dc.contributor.authorCadoni, Gabriella-
dc.contributor.authorDiez, Orland-
dc.contributor.authorFerris, Robert L.-
dc.contributor.authorStefansson, Kari-
dc.contributor.authorCannon-Albright, Lisa A.-
dc.contributor.authorWeinberg, Clarice R.-
dc.contributor.authorMcGuffog, Lesley-
dc.contributor.authorMannermaa, Arto-
dc.contributor.authorGoldberg, Mark S.-
dc.contributor.authorGreene, Mark H.-
dc.contributor.authorMaehle, Lovise-
dc.contributor.authorYannoukakos, Drakoulis-
dc.contributor.authorGarber, Judy-
dc.contributor.authorWebb, Penelope M.-
dc.contributor.authorPejovic, Tanja-
dc.contributor.authorToland, Amanda E.-
dc.contributor.authorHuntsman, David G.-
dc.contributor.authorDörk, Thilo-
dc.contributor.authorWhittemore, Alice S.-
dc.contributor.authorHung, Rayjean J.-
dc.contributor.authorGarcía-Closas, Montserrat-
dc.contributor.authorLi, Li-
dc.contributor.authorFriedman, Eitan-
dc.contributor.authorWolk, Alicja-
dc.contributor.authorOlopade, Olufunmilayo I.-
dc.contributor.authorRisch, Harvey A.-
dc.contributor.authorHamdy, Freddie C.-
dc.contributor.authorBrauch, Hiltrud-
dc.contributor.authorTangen, Catherine M.-
dc.contributor.authorMiddha, Pooja-
dc.contributor.authorTerry, Mary Beth-
dc.contributor.authorStanford, Janet L.-
dc.contributor.authorKraft, Peter-
dc.contributor.authorMontagna, Marco-
dc.contributor.authorBrenton, James D.-
dc.contributor.authorRoobol, Monique J.-
dc.contributor.authorHampe, Jochen-
dc.contributor.authorLubiński, Jan-
dc.contributor.authorStone, Jennifer-
dc.contributor.authorBrenner, Hermann-
dc.contributor.authorNeal, David E.-
dc.contributor.authorPandha, Hardev-
dc.contributor.authorSorensen, Karina Dalsgaard-
dc.contributor.authorCaldés, Trinidad-
dc.contributor.authorBoccia, Stefania-
dc.contributor.authorStintzing, Sebastian-
dc.contributor.authorWeinstein, Stephanie-
dc.contributor.authorChan, Andrew T.-
dc.contributor.authorEeles, Rosalind A.-
dc.contributor.authorHaiman, Christopher A.-
dc.contributor.authorEllberg, Carolina-
dc.date.accessioned2020-10-15T11:17:47Z-
dc.date.available2020-10-15T11:17:47Z-
dc.date.issued2019-01-25-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/2445/171263-
dc.description.abstractQuantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.-
dc.format.extent23 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherNature Publishing Group-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41467-018-08054-4-
dc.relation.ispartofNature Communications, 2019, vol. 10, p. 431-
dc.relation.urihttps://doi.org/10.1038/s41467-018-08054-4-
dc.rightscc-by (c) Jiang et al., 2019-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.subject.classificationCàncer-
dc.subject.classificationEtiologia-
dc.subject.otherCancer-
dc.subject.otherEtiology-
dc.titleShared heritability and functional enrichment across six solid cancers-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec698689-
dc.date.updated2020-10-15T11:17:47Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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