Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171293
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dc.contributor.authorFernández García, Sara-
dc.contributor.authorConde Berriozábal, Sara-
dc.contributor.authorGarcía, Esther-
dc.contributor.authorGort Paniello, Clara-
dc.contributor.authorBernal Casas, David-
dc.contributor.authorGarcía-Díaz Barriga, Gerardo-
dc.contributor.authorLópez Gil, Xavier-
dc.contributor.authorMuñoz-Moreno, Emma-
dc.contributor.authorSoria, Guadalupe-
dc.contributor.authorCampa, Leticia-
dc.contributor.authorArtigas Pérez, Francesc-
dc.contributor.authorRodríguez Allué, Manuel José-
dc.contributor.authorAlberch i Vié, Jordi-
dc.contributor.authorMasana Nadal, Mercè-
dc.date.accessioned2020-10-16T14:43:20Z-
dc.date.available2020-10-16T14:43:20Z-
dc.date.issued2020-10-05-
dc.identifier.issn2050-084X-
dc.identifier.urihttp://hdl.handle.net/2445/171293-
dc.description.abstractHuntington's disease (HD) is a neurological disorder characterized by motor disturbances. HD pathology is most prominent in the striatum, the central hub of the basal ganglia. The cerebral cortex is the main striatal afferent, and progressive cortico-striatal disconnection characterizes HD. We mapped striatal network dysfunction in HD mice to ultimately modulate the activity of a specific cortico-striatal circuit to ameliorate motor symptoms and recover synaptic plasticity. Multimodal MRI in vivo indicates cortico-striatal and thalamo-striatal functional network deficits and reduced glutamate/glutamine ratio in the striatum of HD mice. Moreover, optogenetically-induced glutamate release from M2 cortex terminals in the dorsolateral striatum (DLS) was undetectable in HD mice and striatal neurons show blunted electrophysiological responses. Remarkably, repeated M2-DLS optogenetic stimulation normalized motor behavior in HD mice and evoked a sustained increase of synaptic plasticity. Overall, these results reveal that selective stimulation of the M2-DLS pathway can become an effective therapeutic strategy in HD.-
dc.format.extent24 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publishereLife Sciences-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.7554/eLife.57017-
dc.relation.ispartofeLife, 2020, vol. 9, num. e57017-
dc.relation.urihttps://doi.org/10.7554/eLife.57017-
dc.rightscc-by (c) Fernández García, Sara et al., 2020-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.subject.classificationCorea de Huntington-
dc.subject.classificationEscorça cerebral-
dc.subject.classificationModels animals en la investigació-
dc.subject.otherHuntington's chorea-
dc.subject.otherCerebral cortex-
dc.subject.otherAnimal models in research-
dc.titleM2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's Disease-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec703778-
dc.date.updated2020-10-16T14:43:20Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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