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Title: Plasma YKL-40 in the spectrum of neurodegenerative dementia
Author: Villar Piqué, Anna
Schmitz, Matthias
Hermann, Peter
Goebel, Stefan
Bunck, Timothy
Varges, Daniela
Ferrer, Isidro (Ferrer Abizanda)
Riggert, Joachim
Llorens Torres, Franc
Zerr, Inga
Keywords: Demència
Malaltia d'Alzheimer
Alzheimer's disease
Issue Date: 12-Jul-2019
Publisher: BioMed Central
Abstract: Background: Increased plasma YKL-40 has been reported in Alzheimer's disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegenerative dementias. Methods: YKL-40 was quantified in the plasma of 315 cases, including healthy controls (HC), neurological disease controls (ND), AD, vascular dementia (VaD), frontotemporal dementia (FTD), sporadic Creutzfeldt-Jakob disease (CJD) and Lewy body dementia (LBD). Diagnostic accuracy in the differential diagnostic context and influence of age and gender was assessed. Results: Highest YKL-40 levels were detected in CJD, followed by LBD, VaD, AD, FTD, ND and HC. YKL-40 was associated to age but not to sex. After controlling for age, YKL-40 was significantly elevated in CJD compared to HC (p<0.001), ND, AD and VaD (p<0.01) and in LBD compared to HC (p<0.05). In CJD, YKL-40 concentrations were significantly higher at late disease stages. Conclusions: Plasma YKL-40 is significantly elevated in CJD regardless of clinical and genetic parameters, with moderate diagnostic accuracy in the discrimination from control cases. Our study discards a potential use of this biomarker in the differential diagnostic context but opens the possibility to be explored as a marker for CJD monitoring.
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It is part of: Journal of Neuroinflammation, 2019, vol. 16
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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