Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171498
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRodríguez Matellán, Alberto-
dc.contributor.authorAlcazar, Noelia-
dc.contributor.authorHernández, Félix-
dc.contributor.authorSerrano Marugán, Manuel-
dc.contributor.authorÁvila, Jesús-
dc.date.accessioned2020-10-23T16:04:23Z-
dc.date.available2020-10-23T16:04:23Z-
dc.date.issued2020-10-22-
dc.identifier.urihttp://hdl.handle.net/2445/171498-
dc.description.abstractPost-translational epigenetic modifications take place in mouse neurons of the dentate gyrus (DG) with age. Here, we report that age-dependent reduction in H3K9 trimethylation (H3K9me3) is prevented by cyclic induction of the Yamanaka factors used for cell reprogramming. Interestingly, Yamanaka factors elevated the levels of migrating cells containing the neurogenic markers doublecortin and calretinin, and the levels of the NMDA receptor subunit GluN2B. These changes could result in an increase in the survival of newborn DG neurons during their maturation and higher synaptic plasticity in mature neurons. Importantly, these cellular changes were accompanied by an improvement in mouse performance in the object recognition test over long time. We conclude that transient cyclic reprogramming in vivo in the central nervous system could be an effective strategy to ameliorate aging of the central nervous system and neurodegenerative diseases.ca
dc.format.extent17 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoengca
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.stemcr.2020.09.010-
dc.relation.ispartofStem Cell Reports, 2020-
dc.relation.urihttps://doi.org/10.1016/j.stemcr.2020.09.010-
dc.rightscc by-nc-nd (c) Rodríguez Matellán et al., 2020-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.classificationEpigenèticacat
dc.subject.classificationMalalties neurodegenerativescat
dc.subject.classificationRatolins (Animals de laboratori)cat
dc.subject.otherEpigeneticseng
dc.subject.otherNeurodegenerative diseaseseng
dc.subject.otherMice (Laboratory animals)eng
dc.titleIn Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Miceca
dc.typeinfo:eu-repo/semantics/articleca
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.doi10.1016/j.stemcr.2020.09.010-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/669622/EU//CELLPLASTICITY-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca
dc.identifier.pmid33096049-
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))



This item is licensed under a Creative Commons License Creative Commons