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Title: Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study
Author: Baumeister, Sebastian E.
Schlesinger, Sabrina
Aleksandrova, Krasimira
Jochem, Carmen
Jenab, Mazda
Gunter, Marc J.
Overvad, Kim
Tjønneland, Anne
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Fournier, Agnès
Kühn, Tilman
Kaaks, Rudolf
Pischon, Tobias
Boeing, Heiner
Trichopoulou, Antonia
Bamia, Christina
Vecchia, Carlo La
Masala, Giovanna
Panico, Salvatore
Fasanelli, Francesca
Tumino, Rosario
Grioni, Sara
Bueno de Mesquita, H. Bas
Vermeulen, Roel
May, Anne M.
Borch, Kristin B.
Oyeyemi, Sunday O.
Ardanaz, Eva
Rodríguez Barranco, Miguel
Chirlaque, María Dolores
Félez Nóbrega, Mireia
Sonestedt, Emily
Ohlsson, Bodil
Hemmingsson, Oskar
Werner, Mårten
Pérez Cornago, Aurora
Ferrari, Pietro
Stepien, Magdalena
Freisling, Heinz
Tsilidis, Konstantinos K.
Ward, Heather
Riboli, Elio
Weiderpass, Elisabete
Leitzmann, Michael F.
Keywords: Càncer de fetge
Liver cancer
Issue Date: 1-May-2019
Publisher: Elsevier
Abstract: Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. Weexamined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC). Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection). Results: In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC. Conclusions: These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity. Lay summary: In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Note: Versió postprint del document publicat a:
It is part of: Journal of Hepatology, 2019, vol. 70, num. 5, p. 885-892
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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