Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171543
Title: Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
Author: Watson, Hunna J.
Yilmaz, Zeynep
Thorntont, Laura M.
Hubel, Christopher
Coleman, Jonathan R. I.
Gaspar, Helena A.
Bryois, Julien
Hinney, Anke
Leppa, Virpi M.
Mattheisen, Manuel
Medland, Sarah E.
Pantel, Jacques
Degortes, Daniela
Farmer, Anne
Hauser, Joanna
Föcker, Manuel
Petersen, Liselotte
Lissowska, Jolanta
Buehren, Katharina
Juréus, Anders
Zipfel, Stephan
Ricca, Valdo
Danner, Unna N.
Giuranna, Johanna
Horwood, L. John
Lichtenstein, Paul
Slopien, Agnieszka
Alfredsson, Lars
McDevitt, Sara
Ripatti, Samuli
Kalsi, Gursharan
O’Toole, Julie K.
Zerwas, Stephanie
Hanscombe, Ken B.
Marshall, Christian R.
Stuber, Garret D.
van Elburg, Annemarie A.
Clementi, Maurizio
Duncan, Laramie E.
Micali, Nadia
Mattingsdal, Morten
Munn-Chernoff, Melissa A.
Whiteman, David C.
Jiménez-Murcia, Susana
Forzan, Monica
Zeggini, Eleftheria
Bulik, Cynthia M.
Herpertz-Dahlmann, Beate
Gorwood, Philip
Keski-Rahkonen, Anna
Helder, Sietske G.
Sorbi, Sandro
Estivill, Xavier
Lin, Bochao Danae
Huckins, Laura M.
Tsitsika, Artemis
Navratilova, Marie
Kennedy, Martin
Favaro, Angela
Grove, Jakob
Kiezebrink, Kirsty
Seitz, Jochen
Schork, Nicholas J.
Fischer, Krista
Crowley, James J.
Crawford, Steven
Franklin, Christopher S.
Werge, Thomas
Tziouvas, Konstantinos
Sullivan, Patrick F.
Slof-Op ‘t Landt, Margarita C. T.
Hellard, Stephanie Le
Kim, Youl-Ri
Zwaan, Martina de
Crow, Scott
Slagboom, P. Eline
Levitan, Robert D.
Guillaume, Sébastien
Boden, Joseph M.
Klump, Kelly L.
Kaye, Walter H.
Larsen, Janne T.
Dikeos, Dimitris
Dina, Christian
Schosser, Alexandra
Slachtova, Lenka
Gallinger, Steven
Scherer, Stephen W.
Perica, Vesna Boraska
Widen, Elisabeth
Wagner, Gudrun
Rujescu, Dan
Hudson, James I.
Martin, Nicholas G.
Hakonarson, Hakon
Gordon, Scott
Maj, Mario
Monteleone, Palmiero
Adan, Roger A. H.
Reichborn-Kjennerud, Ted
Boni, Claudette
Tyszkiewicz-Nwafor, Marta
Inoko, Hidetoshi
Guo, Yiran
Santonastaso, Paolo
Raevuori, Anu
Pedersen, Nancy L.
Gonidakis, Fragiskos
Ntalla, Ioanna
Birgegård, Andreas
Cichon, Sven
Szatkiewicz, Jin P.
Schmidt, Ulrike
Fernández Aranda, Fernando
Egberts, Karin
Esko, Tõnu
Hatzikotoulas, Konstantinos
Norring, Claes
Giusti-Rodriguez, Paola
Escaramís, Geòrgia
Walton, Esther
Halmi, Katherine A.
Olsen, Catherine M.
Kas, Martien J. H.
Klareskog, Lars
Tachmazidou, Ioanna
Johnson, Craig
Egberts, Karin
Karwautz, Andreas
Meulenbelt, Ingrid
Magistretti, Pierre J.
Papezova, Hana
Mitchell, James E.
Andreassen, Ole A.
McGuffin, Peter
Li, Dong
Hebebrand, Johannes
Ramoz, Nicolas
Herzog, Wolfgang
Forstner, Andreas J.
Fichter, Manfred M.
Purves, Kirstin L.
Kaprio, Jaakko
Kennedy, James L.
Ritschel, Franziska
Herms, Stefan
Mannik, Katrin
Scherag, André
Nacmias, Benedetta
Marsal, Sara
Baker, Jessica H.
Montgomery, Grant W.
Docampo, Elisa
Boehm, Ilka
Wade, Tracey D.
Breen, Gerome
Giegling, Ina
Palotie, Aarno
Treasure, Janet
Jordan, Jennifer
Via, Maria C. La
Cassina, Matteo
Kaplan, Allan S.
Foretova, Lenka
Roberts, Marion
Monteleone, Alessio Maria
Ripke, Stephan
Ando, Tetsuya
Brandt, Harry
Lilenfeld, Lisa
Dedoussis, George
Tenconi, Elena
Metspalu, Andres
Pearson, John F.
Knudsen, Gun Peggy S.
Ophoff, Roel A.
Bergen, Andrew W.
Parker, Richard
Mortensen, Preben Bo
Gratacòs, Mònica
Berrettini, Wade H.
Ehrlich, Stefan
Kirk, Katherine M.
Dick, Danielle M.
Pinto, Dalila
Tozzi, Federica
Woodside, D. Blake
Davis, Oliver S. P.
Rybakowski, Filip
Tortorella, Alfonso
Henders, Anjali K.
Burghardt, Roland
Rotondo, Alessandro
Luykx, Jurjen
Dmitrzak-Weglarz, Monika
Rabionet Janssen, Raquel
Imgart, Hartmut
van Furth, Eric F.
Janout, Vladimir
Yao, Shuyang
Karhunen, Leila
Landén, Mikael
Courtet, Philippe
Padyukov, Leonid
Świątkowska, Beata
Strober, Michael
Kaminská, Deborah
Julià, Antonio
Cone, Roger D.
Mitchell, Karen
DeSocio, Janiece E.
Keywords: Anorèxia nerviosa
Genòmica
Anorexia nervosa
Genomics
Issue Date: 1-Aug-2019
Publisher: Nature Publishing Group
Abstract: Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2,3,4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/s41588-019-0439-2
It is part of: Nature Genetics, 2019, vol. 51, num. 8, p. 1207-1214
URI: http://hdl.handle.net/2445/171543
Related resource: https://doi.org/10.1038/s41588-019-0439-2
ISSN: 1061-4036
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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