Title: | Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa |
Author: | Watson, Hunna J. Yilmaz, Zeynep Thorntont, Laura M. Hubel, Christopher Coleman, Jonathan R. I. Gaspar, Helena A. Bryois, Julien Hinney, Anke Leppa, Virpi M. Mattheisen, Manuel Medland, Sarah E. Jiménez-Murcia, Susana Forzan, Monica Zeggini, Eleftheria Bulik, Cynthia M. Herpertz-Dahlmann, Beate Gorwood, Philip Raevuori, Anu Keski-Rahkonen, Anna Helder, Sietske G. Boden, Joseph M. Wade, Tracey D. Sorbi, Sandro Estivill, Xavier, 1955- Lin, Bochao Danae Huckins, Laura M. Tsitsika, Artemis Navratilova, Marie Kennedy, Martin Favaro, Angela Pedersen, Nancy L. Grove, Jakob Breen, Gerome Ntalla, Ioanna Kiezebrink, Kirsty Seitz, Jochen Schork, Nicholas J. Fischer, Krista Crowley, James J. Crawford, Steven Franklin, Christopher S. Werge, Thomas Tziouvas, Konstantinos Giegling, Ina Gonidakis, Fragiskos Ehrlich, Stefan Sullivan, Patrick F. Klump, Kelly L. Kaye, Walter H. Larsen, Janne T. Dikeos, Dimitris Dina, Christian Schosser, Alexandra Slachtova, Lenka Palotie, Aarno Gallinger, Steven Scherer, Stephen W. Perica, Vesna Boraska Kirk, Katherine M. Birgegård, Andreas Widen, Elisabeth Wagner, Gudrun Rujescu, Dan Hudson, James I. Martin, Nicholas G. Treasure, Janet Hakonarson, Hakon Gordon, Scott Maj, Mario Monteleone, Palmiero Dick, Danielle M. Adan, Roger A. H. Pantel, Jacques Reichborn-Kjennerud, Ted Cichon, Sven Szatkiewicz, Jin P. Jordan, Jennifer Schmidt, Ulrike Fernández Aranda, Fernando Egberts, Karin Esko, Tõnu Hatzikotoulas, Konstantinos Pinto, Dalila Norring, Claes Giusti-Rodriguez, Paola Escaramís Babiano, Geòrgia Degortes, Daniela Petersen, Liselotte Walton, Esther Halmi, Katherine A. Olsen, Catherine M. Kas, Martien J. H. Klareskog, Lars Tachmazidou, Ioanna Tozzi, Federica Johnson, Craig Egberts, Karin Karwautz, Andreas Via, Maria C. La Meulenbelt, Ingrid Farmer, Anne Magistretti, Pierre J. Papezova, Hana Mitchell, James Andreassen, Ole A. McGuffin, Peter Woodside, D. Blake Li, Dong Hebebrand, Johannes Cassina, Matteo Ramoz, Nicolas Herzog, Wolfgang Forstner, Andreas J. Hauser, Joanna Fichter, Manfred M. Purves, Kirstin L. Kaprio, Jaakko Kennedy, James L. Davis, Oliver S. P. Ritschel, Franziska Tortorella, Alfonso Herms, Stefan Mannik, Katrin Scherag, André Nacmias, Benedetta Marsal, Sara Föcker, Manuel Baker, Jessica H. Montgomery, Grant W. Docampo, Elisa Rybakowski, Filip Slof-Op ‘t Landt, Margarita C. T. Boehm, Ilka Kaplan, Allan S. Foretova, Lenka Roberts, Marion Monteleone, Alessio Maria Ripke, Stephan Ando, Tetsuya Brandt, Harry Lilenfeld, Lisa Lissowska, Jolanta Dedoussis, George Hellard, Stephanie Le Juréus, Anders Tenconi, Elena Metspalu, Andres Pearson, John F. Knudsen, Gun Peggy S. Ophoff, Roel A. Bergen, Andrew W. Parker, Richard Mortensen, Preben Bo Gratacòs, Mònica Kim, Youl-Ri Buehren, Katharina Boni, Claudette Berrettini, Wade H. Henders, Anjali K. Burghardt, Roland Rotondo, Alessandro Luykx, Jurjen Dmitrzak-Weglarz, Monika Rabionet Janssen, Raquel Imgart, Hartmut Zwaan, Martina de van Furth, Eric F. Janout, Vladimir Yao, Shuyang Tyszkiewicz-Nwafor, Marta Zipfel, Stephan Karhunen, Leila Landén, Mikael Courtet, Philippe Padyukov, Leonid Świątkowska, Beata Crow, Scott Strober, Michael Kaminská, Deborah Julià, Antonio Cone, Roger D. Inoko, Hidetoshi Mitchell, Karen Ricca, Valdo DeSocio, Janiece E. Danner, Unna N. Giuranna, Johanna Slagboom, P. Eline Horwood, L. John Lichtenstein, Paul Slopien, Agnieszka Alfredsson, Lars McDevitt, Sara Guo, Yiran Ripatti, Samuli Kalsi, Gursharan O’Toole, Julie K. Zerwas, Stephanie Levitan, Robert D. Hanscombe, Ken B. Marshall, Christian R. Stuber, Garret D. van Elburg, Annemarie A. Clementi, Maurizio Duncan, Laramie E. Santonastaso, Paolo Micali, Nadia Mattingsdal, Morten Munn-Chernoff, Melissa A. Guillaume, Sébastien Whiteman, David C. |
Keywords: | Anorèxia nerviosa Genòmica Anorexia nervosa Genomics |
Issue Date: | 1-Aug-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2,3,4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/s41588-019-0439-2 |
It is part of: | Nature Genetics, 2019, vol. 51, num. 8, p. 1207-1214 |
URI: | http://hdl.handle.net/2445/171543 |
Related resource: | https://doi.org/10.1038/s41588-019-0439-2 |
ISSN: | 1061-4036 |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.